June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Lower Fetal Haemoglobin Levels at 31- and 34-weeks Post Menstrual Age is Associated with the Development of Retinopathy of Prematurity
Author Affiliations & Notes
  • Kim Jiramongkolchai
    Ophthalmology, Wilmer Eye Institute, Baltimore, Maryland, United States
  • Michael Repka
    Ophthalmology, Wilmer Eye Institute, Baltimore, Maryland, United States
  • jing tian
    Johns Hopkins University, Maryland, United States
  • Sue Aucott
    Johns Hopkins University, Maryland, United States
  • Megan E Collins
    Ophthalmology, Wilmer Eye Institute, Baltimore, Maryland, United States
  • Courtney Kraus
    Ophthalmology, Wilmer Eye Institute, Baltimore, Maryland, United States
  • Julia Clemens
    University of Vermont, Vermont, United States
  • Mia Feller
    Georgetown University, District of Columbia, United States
  • Irina Burd
    Johns Hopkins University, Maryland, United States
  • Marina Roizenblatt
    Federal University of São Paulo, Brazil
  • Morton Goldberg
    Ophthalmology, Wilmer Eye Institute, Baltimore, Maryland, United States
  • J Fernando Arevalo
    Ophthalmology, Wilmer Eye Institute, Baltimore, Maryland, United States
  • Peter L Gehlbach
    Ophthalmology, Wilmer Eye Institute, Baltimore, Maryland, United States
  • James T Handa
    Ophthalmology, Wilmer Eye Institute, Baltimore, Maryland, United States
  • Footnotes
    Commercial Relationships   Kim Jiramongkolchai, None; Michael Repka, None; jing tian, None; Sue Aucott, None; Megan Collins, None; Courtney Kraus, None; Julia Clemens, None; Mia Feller, None; Irina Burd, None; Marina Roizenblatt, None; Morton Goldberg, None; J Fernando Arevalo, None; Peter Gehlbach, None; James Handa, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 2197. doi:
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      Kim Jiramongkolchai, Michael Repka, jing tian, Sue Aucott, Megan E Collins, Courtney Kraus, Julia Clemens, Mia Feller, Irina Burd, Marina Roizenblatt, Morton Goldberg, J Fernando Arevalo, Peter L Gehlbach, James T Handa; Lower Fetal Haemoglobin Levels at 31- and 34-weeks Post Menstrual Age is Associated with the Development of Retinopathy of Prematurity. Invest. Ophthalmol. Vis. Sci. 2020;61(7):2197.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Previous studies have suggested that lower mean fetal haemoglobin (HbF) levels is associated with an increased risk for developing retinopathy of prematurity (ROP). Lower HbF levels may lead to high oxygen exposure to the developing retina thereby increasing the risk of acute ROP. In this study, we characterize the temporal relationship of HbF levels and the development of ROP.

Methods : This is a single institution prospective observational cohort study. Pre-term infants (born < 31 weeks gestational age or <1500 g) with HbF measured at birth (cord blood), 31-, 34-, and 37-weeks post-menstrual age (PMA); and at least one ROP exam, were enrolled.

Results : A total of 60 pre-term infants (28 females, 47%) were enrolled. At 31-, 34-, 37- weeks PMA, infants with ROP (mild=Type 2 or less severe and severe=Type 1 ROP) had statistically lower percentages of HbF than infants with no ROP (9.7±2.9 and 28.2±15 vs 67.1±29.6; p<0.0001; 32.5 and 23.3±14.7 vs 60.1±25; p<0.005; 41.6 and 31.9±15.8 vs 60.2±20.0; p<0.0019). Infants with HbF levels in the lowest tercile at 31-weeks PMA were 7.6 times more likely to develop mild and severe ROP (95% CI 2.1 to 24.0, p-value=0.0006) and this risk increased to 12.3 times (95% CI: 2.6-59.0, p-value=0.0017) at 34-weeks PMA.

Conclusions : Low HbF levels at 31- and 34-weeks PMA are associated with significantly increased risk of developing ROP. The decrease in HbF precedes the development of ROP and may be important in its pathogenesis.

This is a 2020 ARVO Annual Meeting abstract.

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