June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Macular thickness and peripapillary RNFL thickness in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS)
Author Affiliations & Notes
  • Bryan Ming-Tak Wong
    Faculty of Medicine, University of Toronto, Markham, Ontario, Canada
  • Christopher Hudson
    School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada
    Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
  • Faryan Tayyari
    Kensington Eye Institute, Toronto, Ontario, Canada
  • Saba Samet
    Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
  • Efrem D Mandelcorn
    Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
    Kensington Eye Institute, Toronto, Ontario, Canada
  • Edward Margolin
    Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
    Kensington Eye Institute, Toronto, Ontario, Canada
  • Elizabeth Finger
    Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada
  • Sandra E. Black
    Department of Medicine (Neurology), Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
  • David Tang-Wai
    Department of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada
  • Lorne Zinman
    Department of Medicine (Neurology), Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
  • Brian Tan
    Baycrest Hospital, Toronto, Ontario, Canada
  • Hyejung Jung
    Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
  • Mario Masellis
    Department of Medicine (Neurology), Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
  • Morris Freedman
    Baycrest Hospital, Toronto, Ontario, Canada
  • Maria Carmela Tartaglia
    Department of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada
  • Wendy Hatch
    Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
    Kensington Eye Institute, Toronto, Ontario, Canada
  • Footnotes
    Commercial Relationships   Bryan Wong, None; Christopher Hudson, None; Faryan Tayyari, None; Saba Samet, None; Efrem Mandelcorn, Bayer (R), Novartis (R); Edward Margolin, None; Elizabeth Finger, None; Sandra Black, ADDF (F), Biogen Idec (F), Brain Canada (F), CIHR (F), CPSR (F), Eli Lilly (F), GE Healthcare (F), Genentech (F), HSFC (F), Leducq (F), NIH (F), Novartis (F), Ontario Brain Institute (F), Optina (F), Pfizer (C), Roche (C), Roche (F); David Tang-Wai, None; Lorne Zinman, None; Brian Tan, None; Hyejung Jung, None; Mario Masellis, None; Morris Freedman, Methods and kits for the differential diagnosis of Alzheimer's disease versus frontotemporal dementia using blood biomarkers (P); Maria Carmela Tartaglia, None; Wendy Hatch, None
  • Footnotes
    Support  Toronto Western Hospital Practice Plan (Dr. Robert Devenyi), and Ontario Brain Institute (OBI)
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 2538. doi:
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      Bryan Ming-Tak Wong, Christopher Hudson, Faryan Tayyari, Saba Samet, Efrem D Mandelcorn, Edward Margolin, Elizabeth Finger, Sandra E. Black, David Tang-Wai, Lorne Zinman, Brian Tan, Hyejung Jung, Mario Masellis, Morris Freedman, Maria Carmela Tartaglia, Wendy Hatch; Macular thickness and peripapillary RNFL thickness in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Invest. Ophthalmol. Vis. Sci. 2020;61(7):2538.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Frontotemporal dementia (FTD) includes a group of neurodegenerative syndromes associated with two main proteinopathies: tauopathy and TAR DNA-binding protein 43 (TDP-43) proteinopathy. The difficulty of predicting underlying pathology in vivo in FTD precludes the delivery of targeted therapy. Some syndromes are reliably associated with either tau (progressive supranuclear palsy [PSP]) or TDP-43 (semantic variant primary progressive aphasia [svPPA] and amyotrophic lateral sclerosis [ALS]). We compared macular retinal thickness and peripapillary retinal nerve fibre layer (pRNFL) thickness between participants with tauopathy (PSP) and TDP-43 proteinopathy (svPPA and ALS) to examine the potential of spectral domain optical coherence tomography (SD-OCT) as an inexpensive, non-invasive tool to detect possible retinal biomarkers differentiating these pathologies in vivo.

Methods : This was an analysis of a prospective, multi-centre, observational study. Macular and pRNFL SD-OCT images were acquired in both eyes of each participant using the Heidelberg Spectralis (Heidelberg, Germany) as part of the Ontario Neurodegenerative Disease Research Initiative. We analyzed macular thickness in the central 1mm diameter zone, four sectors (superior, inferior, nasal, and temporal) within a 3mm diameter circular grid centred on the fovea, as well as global and sectoral pRNFL thicknesses. Linear mixed model methods adjusting for age and gender were used to compare the thickness values between the tau (PSP) and TDP-43 (svPPA and ALS) groups.

Results : Mean group ages for tauopathy (9 eyes of 5 subjects) and TDP-43 (34 eyes of 17 subjects) were 72.7 (SD=5.2) and 62.2 (SD=9.1) years, respectively. We found no significant difference between mean retinal thickness in the central macular zone of the tauopathy (272.21μm, SD=9.81) and TDP-43 (274.35μm, SD=4.76) groups (p=0.852). A trend to statistically different mean pRNFL thickness was found in the inferior-nasal sector between the groups, with the tauopathy group having a thicker pRNFL (difference in means=20.99μm, SD=10.84, p=0.068).

Conclusions : There was no significant difference in macular or pRNFL thickness between tauopathy and TDP-43 groups, although there was a general trend for global and sectoral pRNFL to be thicker in the tauopathy group. Future work should include larger sample sizes, longitudinal analysis, and sub-layer analysis.

This is a 2020 ARVO Annual Meeting abstract.

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