June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Using OCT to confirm early signs of Type 2 Macular Telangiectasia in fellow eyes. (India Mactel Report 1).
Author Affiliations & Notes
  • Giridhar Anantharaman
    Vitreoretina, Giridhar Eye institute, Cochin, India
  • Sobha Sivaprasad
    Moorfields Eye Hospital, London, United Kingdom
  • Divya Alex
    Vitreoretina, Giridhar Eye institute, Cochin, India
  • Mahesh Gopalakrishnan
    Vitreoretina, Giridhar Eye institute, Cochin, India
  • George Mayanath
    Vitreo Retina, Aravind Eye Hospital, Coimbatore, Tamil Nadu, India
  • Apoorva Ayachit
    Vitreo Retina, M.M. Joshi Eye Institute, Hubli, Karnataka, India
  • Footnotes
    Commercial Relationships   Giridhar Anantharaman, None; Sobha Sivaprasad, None; Divya Alex, None; Mahesh Gopalakrishnan, None; George Mayanath, None; Apoorva Ayachit, None
  • Footnotes
    Support  This study was performed as part of the Ornate India project funded by the GCRF-UKRI (grant ref: MR/P027881/1)
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 2555. doi:
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      Giridhar Anantharaman, Sobha Sivaprasad, Divya Alex, Mahesh Gopalakrishnan, George Mayanath, Apoorva Ayachit; Using OCT to confirm early signs of Type 2 Macular Telangiectasia in fellow eyes. (India Mactel Report 1).. Invest. Ophthalmol. Vis. Sci. 2020;61(7):2555.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Blue light reflectance imaging is useful in detecting early signs of Type 2 Macular Telangiectasia (Mactel). However, this imaging is not available in many clinics in India where Mactel is common. The aim of this study is to report early OCT features of fellow eyes of patients with clinical presentation of unilateral Mactel.

Methods : This is a retrospective study of OCT features in fellow eyes of patients with unilateral clinical presentation of Mactel. The demography and clinical presentation of 1024 eyes were collated.

Results : Twenty nine eyes with unilateral Mactel cofirmed by OCT, infrared and autofluorescence were included. The mean age of these patients was 62.5 years with female predilection (4:1). Mean best corrected visual acuity of the affected eye was logmar 0.25 and unaffected eye was 0.16. In the affected eyes, hypo-reflective spaces in the inner retina were found in all eyes. Collapse of the inner retina was noted in 37.5% of the affected eyes. Mean EZ and ELM loss was 492μm (SD161) and 451μm (SD152) respectively. Subfoveal EZ loss was noted in 48% of the affected eyes. RPE proliferation was noted in 22.5% of the affected eyes. Mean central subfoveal thickness was 170μm (SD37) in affected eyes. In the fellow eyes, the central subfoveal thickness was 200 μm (SD 28μm) and the temporal retinal thickness was 140 μm (SD 39μm) on Spectralis Heidelberg Engineering, Germany. These parameters are thinner than the normative retinal thickness data in these subfields in males and females.

Conclusions : Although these cases with advanced presentation of Mactel OCT features occurred in only one eye, the foveal and temporal thinning in the fellow eye compared to corresponding normative data indicate that thinning of the retina may be an early sign of Mactel and can be used as a surrogate marker to confirm bilateral assymetric Mactel.

This is a 2020 ARVO Annual Meeting abstract.

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