June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
PERIPAPILLARY RETINAL NERVE FIBER LAYER THICKNESS LONGITUDINAL CHANGES AND ASSOCIATED FACTORS IN AN ELDERLY POPULATION: THE ALIENOR STUDY.
Cedric Schweitzer; GREGOIRE CHEVREAU; Audrey Cougnard-Gregoire; Mélanie LE GOFF; lauriane salinas; Marie-Noëlle Delyfer; Marie B Rougier; Jean-Francois Korobelnik; Cecile Delcourt
Author Affiliations & Notes
  • Cedric Schweitzer
    OPHTHALMOLOGY, BORDEAUX UNIVERSITY , Bordeaux, France
  • GREGOIRE CHEVREAU
    OPHTHALMOLOGY, BORDEAUX UNIVERSITY , Bordeaux, France
  • Audrey Cougnard-Gregoire
    OPHTHALMOLOGY, BORDEAUX UNIVERSITY , Bordeaux, France
  • Mélanie LE GOFF
    OPHTHALMOLOGY, BORDEAUX UNIVERSITY , Bordeaux, France
  • lauriane salinas
    OPHTHALMOLOGY, BORDEAUX UNIVERSITY , Bordeaux, France
  • Marie-Noëlle Delyfer
    OPHTHALMOLOGY, BORDEAUX UNIVERSITY , Bordeaux, France
  • Marie B Rougier
    OPHTHALMOLOGY, BORDEAUX UNIVERSITY , Bordeaux, France
  • Jean-Francois Korobelnik
    OPHTHALMOLOGY, BORDEAUX UNIVERSITY , Bordeaux, France
  • Cecile Delcourt
    OPHTHALMOLOGY, BORDEAUX UNIVERSITY , Bordeaux, France
  • Footnotes
    Commercial Relationships   Cedric Schweitzer, alcon (C), allergan (C), bausch (C), hoya (C), novartis (C), thea (C), zeiss (C); GREGOIRE CHEVREAU, None; Audrey Cougnard-Gregoire, thea (R); Mélanie LE GOFF, None; lauriane salinas, None; Marie-Noëlle Delyfer, allergan (C), bausch (C), bayer (C), horama (C), horus (C), novartis (C), thea (C); Marie Rougier, allergan (C), bayer (C), novartis (C), thea (C), zeiss (C); Jean-Francois Korobelnik, allergan (C), bayer (C), beaver visitec (C), horus (C), kanghong (C), krys (C), nanoretina (C), novartis (C), novonordisk (C), oxurion (C), roche (C), thea (C), zeiss (C); Cecile Delcourt, allergan (C), Bausch & Lomb (C), Novartis (C), thea (C)
  • Footnotes
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Investigative Ophthalmology & Visual Science June 2020, Vol.61, 2573. doi:
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      Cedric Schweitzer, GREGOIRE CHEVREAU, Audrey Cougnard-Gregoire, Mélanie LE GOFF, lauriane salinas, Marie-Noëlle Delyfer, Marie B Rougier, Jean-Francois Korobelnik, Cecile Delcourt; PERIPAPILLARY RETINAL NERVE FIBER LAYER THICKNESS LONGITUDINAL CHANGES AND ASSOCIATED FACTORS IN AN ELDERLY POPULATION: THE ALIENOR STUDY.. Invest. Ophthalmol. Vis. Sci. 2020;61(7):2573.

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Abstract

Purpose : To investigate the longitudinal changes of peripapillary retinal nerve fiber layer thickness (RNFLT) and associated factors using spectral-domain optical coherence tomography (SD-OCT).

Methods : The ALIENOR (Antioxydants, Lipides Essentiels, Nutrition and maladies OculaiRes) Study is a population-based cohort study on age-related eye diseases performed in elderly residents of Bordeaux, aged 73 years and older.Between April 2009, and May 2017, 624 participants underwent clinical and ophthalmological examinations every two years.Mean global and sectorialRNFLT values were obtained using SD-OCT (Spectralisâ, Heidelberg Engineering, Germany)and a 3.45mm circle scan diameter centered on the optic disc. Association of ophthalmological and clinical factors with RNFL changes were performed in a multivariate analysis.

Results : The mean age was 82.2±3.7 years, 413 participants had complete data.The mean follow-up duration was 5.2±1.8 years. The mean rate of RNFLT loss per year was -0.68 mm±0.06 per year for global and was higher in superotemporal and inferotemporal sectors(-1.02±0.11mmand -1.15±0.10mmrespectively), followed by inferonasal (-0.82±0.08mm), superonasal (-0.62±0.09mm), temporal (-0.52±0.08mm) and nasal sectors (-0.25±0.07mm). High plasma HDL-cholesterol (≥1.03 mmol/l in men; ≥1.29 mmol/l in women) and the use of hydrophilic statins had a positive association with longitudinal RNFLT (Bêta = 0.33, p=0.041 and Bêta = 0.58, p=0.0046 respectively).

Conclusions : Our longitudinal study confirms that peripapillary RNFLT decreases with time in elderly subjects. High plasma HDL-cholesterol and hydrophilic statins use were associated with a slower RNFLT decrease over time. Age-related changes should be taken into consideration when interpreting RNFLT values using SD-OCT to assess the diagnosis or the progression of optic nerve head diseases.

This is a 2020 ARVO Annual Meeting abstract.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2015 Association for Research in Vision and Ophthalmology.
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