Abstract
Purpose :
To develop a screening tool for age-related macular degeneration (AMD), we evaluated multiply scattered light images from the Digital Light Ophthalmoscope (DLO) (Aeon Imaging, Bloomington, IN), and compared the results from a commercially available optical coherence tomography (OCT) system (Spectralis, Heidelberg, Germany).
Methods :
Twenty subjects known not to have exudative AMD had images taken in both eyes, centered on both the macula and the optic nerve head. Nonmydriatic multiply scattered light images were taken with the DLO, which has 860nm illumination and 37 deg field. Multiply scattered light imaging was performed by shifting the detection aperture electronically with respect to the illumination. Pairs of 2msec leading and lagging offsets were compared to observe scattering effects in opposite directions, and to estimate lesion area. Subjects were also imaged using a scanning laser ophthalmoscope and OCT system. Vertical B-scans were taken over 10x20 or 15x15 deg, with 11µm spacing. B-scans were graded for drusen and other outer retinal lesions, and then DLO images were reviewed for congruency. Measurements of lesion areas were computed with Matlab (Mathworks, Natick, MA).
Results :
Two subjects were not able to complete the full OCT imaging due to fixation issues, causing excessive testing time. Seventeen of the 20 subjects had a druse or other outer retinal lesion present in at least one B-scan. The areas of lesions correlated well (R2 = 0.9239), suggesting that the same lesions were being detected and measured.
Conclusions :
Lesions identified in OCT B-scans were also found in the DLO multiply scattered light images. The DLO identified pathology over a 37 deg field, and could be used as an easy-to-use, nonmydriatic screening device for identifying early markers of AMD. All subjects were able to be imaged with the DLO, even those with fixation issue, making it a useful screening tool.
This is a 2020 ARVO Annual Meeting abstract.