June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Perfusion characteristics of the optic nerve head and macular region in long-term compared to recently started anti-VEGF treatment
Author Affiliations & Notes
  • Katja B Hatz
    VISTA Klinik, VISTA Klinik Binningen, Binningen, Switzerland
    University of Basel, Basel, Switzerland
  • Cengiz Tuerksever
    VISTA Klinik, VISTA Klinik Binningen, Binningen, Switzerland
  • Footnotes
    Commercial Relationships   Katja Hatz, None; Cengiz Tuerksever, None
  • Footnotes
    Support  This study has been supported in part by CENAUG Foundation, Liechtenstein.
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 2644. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Katja B Hatz, Cengiz Tuerksever; Perfusion characteristics of the optic nerve head and macular region in long-term compared to recently started anti-VEGF treatment. Invest. Ophthalmol. Vis. Sci. 2020;61(7):2644.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To compare the vascular perfusion in peripapillary and macular regions of patients with neovascular age-related macular degeneration (nAMD) with recently started (<5 injections, group 1) and longterm (≥20 injections, group 2) intravitreal anti-VEGF treatment.

Methods : In this cross-sectional prospective study nAMD patients with either < 5 or ≥20 intravitreal treatments were recruited consecutively. Patients with glaucoma or ocular hypertension at baseline of anti-VEGF treatment and patients with history of retinal vascular disease were excluded. The study evaluated perfusion indices (vessel density, flux index, perfusion density) using Swept-Source Optical Coherence Tomography Angiography in the 6x6mm macular region and in the 2mm width annulus of peripapillary region. Further, Spectral-domain Optical Coherence Tomography analysis of the macular and optic nerve head (ONH) region was performed.

Results : 44 eyes of 44 patients were included in the analysis with a mean number of 2.81 ±1 and 35.8±16 injections in group 1 (n=20) and 2 (n=24), respectively. The groups showed no significant differences regarding mean vessel density (p=0.308), mean blood flux index (p=0.678) and retinal nerve fiber layer thickness (p=0.073) of ONH. In the central 3mm and 6mm macular regions there were no significant differences between the groups regarding superficial (p=0.081, p=0.688) and deep perfusion density (p=0.586, p=0.680), but the superficial temporal/nasal perfusion ratio was significantly lower in long-term treated patients (p=0.03) and there was a non-significant trend towards lower deep temporal/nasal perfusion ratio (p=0.067). Superficial perfusion density in the central 3mm and 6mm macular regions was significantly reduced in eyes with larger lesion at baseline (Pearson r=-0.610; r=-0.467). Eyes with subretinal fluid (n=23, 12 group 1, 11 group 2) showed better superficial macular perfusion density in the central 6mm (p=0.048) compared to eyes without subretinal fluid.

Conclusions : Long-term intravitreal anti-VEGF treated nAMD eyes did not show different perfusion characteristics or nerve fiber layer thickness of ONH than eyes with recently started anti-VEGF treatment. This might indicate that long-term anti-VEGF treatment is safe regarding ONH alterations. Smaller lesions and presence of subretinal fluid indicated better superficial macular perfusion density.

This is a 2020 ARVO Annual Meeting abstract.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×