Abstract
Purpose :
Given the important role of basigin (BSG, CD147) gene and non-syndromic high myopia and eye elongation as reported, we speculated that BSG genetic polymorphisms might influence the formation of myopia. The study was to investigate the association between BSG gene polymorphisms and myopia in college student cohort.
Methods :
A total of 158 myopia individuals (refraction ≤-3.00D, SE) and 124 normal controls (refraction between -0.50D and +2.00D, SE) college students participated in the association study. Allelic discrimination assay was performed on five single nucleotide polymorphisms (SNPs) (rs539913003, rs12611131, rs4919862, rs8637 and rs8259) in BSG by direct sequence analysis and restriction fragment length polymorphism (RFLP) of polymerase chain reaction (PCR) products. The genotype, allele and haplotype frequencies of the SNPs between cases and controls were compared by Chi-square test for association analysis.
Results :
Significant differences were found in the genotypes and allele frequencies of the rs12611131 SNP between the myopia and control group, while the frequencies of the C allele and the CC genotype in the myopia group were significantly lower than those in the control group (P<0.05).There was no statistically significant difference in genotype, allele and haplotype frequencies for the other SNPs (rs539913003, rs4919862, rs8637 and rs8259) between the myopia group and the control group.<div> </div><div> </div>
Conclusions :
We do not find a strong evidence to support an association of SNP in BSG with myopia in the Chinese population studied.
This is a 2020 ARVO Annual Meeting abstract.