Investigative Ophthalmology & Visual Science Cover Image for Volume 61, Issue 7
June 2020
Volume 61, Issue 7
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ARVO Annual Meeting Abstract  |   June 2020
Retinal Sensitivity and Depolarization Measured by Polarization-Sensitive Optical Coherence Tomography in Patients with High Myopia
Akira Harimoto; Motoshi Yamamoto; Kayoko Komatsu; Shoko Abe; Nobuyori Aoki; Masahiro Yamanari; Satoshi Sugiyama; Takahiro Minami; Kohei Ueda; Keiko Azuma; Makoto Aihara; Satoshi Kato; Ryo Obata
Author Affiliations & Notes
  • Akira Harimoto
    Ophthalmology, University of Tokyo, Tokyo, Japan
  • Motoshi Yamamoto
    Ophthalmology, University of Tokyo, Tokyo, Japan
  • Kayoko Komatsu
    Ophthalmology, University of Tokyo, Tokyo, Japan
  • Shoko Abe
    Ophthalmology, University of Tokyo, Tokyo, Japan
  • Nobuyori Aoki
    Tomey Corporation, Aichi, Nagoya, Japan
  • Masahiro Yamanari
    Tomey Corporation, Aichi, Nagoya, Japan
  • Satoshi Sugiyama
    Tomey Corporation, Aichi, Nagoya, Japan
  • Takahiro Minami
    Ophthalmology, University of Tokyo, Tokyo, Japan
  • Kohei Ueda
    Ophthalmology, University of Tokyo, Tokyo, Japan
  • Keiko Azuma
    Ophthalmology, University of Tokyo, Tokyo, Japan
  • Makoto Aihara
    Ophthalmology, University of Tokyo, Tokyo, Japan
  • Satoshi Kato
    Ophthalmology, University of Tokyo, Tokyo, Japan
  • Ryo Obata
    Ophthalmology, University of Tokyo, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Akira Harimoto, None; Motoshi Yamamoto, Tomey (R); Kayoko Komatsu, None; Shoko Abe, None; Nobuyori Aoki, AMED (F), Tomey (E), Tomey (P); Masahiro Yamanari, AMED (F), Tomey (E), Tomey (P); Satoshi Sugiyama, AMED (F), Tomey (E), Tomey (P); Takahiro Minami, Tomey (F); Kohei Ueda, None; Keiko Azuma, None; Makoto Aihara, alcon (F), alcon (C), alcon (R), hoya (C), johnson and johnson (F), johnson and johnson (R), kowa (F), kowa (C), kowa (R), novartis (F), novartis (R), otsuka (F), otsuka (C), otsuka (R), pfyzer (F), pfyzer (C), pfyzer (R), santen (F), santen (C), santen (R), senju (F), senju (C), senju (R), wakamoto (F), wakamoto (C); Satoshi Kato, acura (R), Bayer (R), hoya (R), kowa (R), mebix (P), nidec (F), novartis (F), novartis (R), santen (F), santen (R), sanwa (R); Ryo Obata, bayer (R), novartis (R), santen (R), Tomey (F)
  • Footnotes
    Support  This research was supported by AMED under Grant Number JP19he1302011
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 2695. doi:
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      Akira Harimoto, Motoshi Yamamoto, Kayoko Komatsu, Shoko Abe, Nobuyori Aoki, Masahiro Yamanari, Satoshi Sugiyama, Takahiro Minami, Kohei Ueda, Keiko Azuma, Makoto Aihara, Satoshi Kato, Ryo Obata; Retinal Sensitivity and Depolarization Measured by Polarization-Sensitive Optical Coherence Tomography in Patients with High Myopia. Invest. Ophthalmol. Vis. Sci. 2020;61(7):2695.

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Abstract

Purpose : Retinal sensitivity may decrease in high myopia even without choroidal neovascularization or patchy chorioretinal atrophy. The association between retinal sensitivity and the integrity of retinal pigment epithelium (RPE) has not been studied in detail. In the present study, we investigated the association between retinal sensitivity and optical depolarization at the RPE layer measured by Polarization-Sensitive Optical Coherence Tomography (PS-OCT) in patients with high myopia.

Methods : Among patients who visited at University of Tokyo Hospital, 23 highly myopic eyes (age, 66.6±12.3) without history of choroidal neovascularization or patchy chorioretinal atrophy, were included. High myopia was defined as a refractive error of less than -8.0 diopters (D) or an axial length of 26.5 mm or longer. Retinal sensitivity was measured by microperimetry in 25 points within 8 degrees from the fovea. Depolarization was measured by a clinical prototype of PS-OCT. RPE layer was automatically segmented and enface depolarization map was exported. 25 sectors corresponding to the point measured by microperimetry was overlaid to the depolarization map and the mean value in each sector was calculated. We used mixed model to investigate the association between retinal sensitivity, age, axial length, degree of depolarization in the RPE, choroidal thickness, and retinal thickness.

Results : The average and deviation of retinal sensitivity, axial length, choroidal thickness, and retinal thickness was 25.3±1.7dB, 29.6±1.6mm, 82.5±30.7µm and 263.0±33.9µm, respectively. Axial length (β=-0.53 [-0.92 to -0.13], p=0.01), degree of depolarization in the RPE (β=5.0 [1.1 to 9.0], p=0.01) and retinal thickness (β=0.0057 [0.00077 to 0.011], p=0.02) were significantly associated with retinal sensitivity.

Conclusions : Retinal sensitivity and depolarization in the RPE measured with PS-OCT may be associated in patients with high myopia.

This is a 2020 ARVO Annual Meeting abstract.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2025 Association for Research in Vision and Ophthalmology.
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