Abstract
Purpose :
Purpose: Central choroidal thinning is reported in children with history of ROP using optical coherence tomography. ROP is a disease of the inner retina; however, there is evidence that choroidal vasculature is also affected leading to degeneration of outer retina and visual function. The purpose of the study is to review the extent of choroidal loss seen angiographically in infants treated with IVB.
Methods :
Methods: Retrospectively reviewed the fluorescein angiography (FA) images of 62 eyes of 31 IVB monotherapy treated infants performed at an average 65 weeks PMA (9 months chronological age). The eyes with good quality early-mid and late phase imaging were included in the study. The the presence and extent of choroidal hypofluoresence involving the central and or peripheral retina were noted.
Results :
Results: The mean age and birth weight was 24.4 weeks PMA and 683 grams respectively. The infants received IVB monotherapy at an average of 33.5 weeks PMA. 24 of 62 angiography images were of good quality. The reviewed images showed the presence of choroidal hypofluorescence involving central loss and or peripheral lobular loss in early choroidal phase and mid and late phases on FA. 12 eyes demonstrated persistent choroidal loss on sequential FA’s done as late past three years of age.
Conclusions :
Conclusions: The study demonstrates the sustained choroidal vascular loss angiographically both central and peripheral in infants with ROP beyond three years of age. It highlights the role of choroidal involution in progressive outer retinal function with prematurity. The subsequent loss of retinal pigment epithelium and photoreceptors from choroidal loss can affect the visual outcomes in infants with ROP.
This is a 2020 ARVO Annual Meeting abstract.