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Alexander Crane, Gaurav Srivastava, Albert S Khouri; XEN Gel Implant in Refractory Glaucoma: A Retrospective Study. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3132.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the efficacy and safety of the XEN45 Gelstent implant in patients with refractory glaucoma.
This is a retrospective, single center chart review conducted on consecutive glaucoma patients undergoing XEN45 Gel stent implantation from 2017-2019. Primary outcome was meeting success criteria, with complete success defined as 20% reduction in intra-ocular pressure (IOP) with no IOP lowering medications, and qualified success defined as 20% reduction in IOP with IOP lowering medications. IOP, visual acuity (VA), and number of glaucoma medications (GMs) were recorded pre-operatively, in addition to 3 and 6 months post-operatively (POM3 and POM6, respectively). Refractory glaucoma defined as previously failed filtering/shunting surgery or cycloablativeprocedure and/or uncontrolled IOP on maximally tolerated medical therapy. Exclusion criteria included lack of follow-up at POM3 or POM6. Significance determined by t-test, with alpha=0.05. Data presented as (mean +/- standard deviation) unless otherwise specified.
Twenty-one patients with refractory glaucoma were identified; baseline characteristics include a mean age of 69, 7 females (33%), pre-op IOP (20.8 +/- 6.7 mmHg), and pre-op GMs (3.1 +/- 1.2). At POM3 (n=12) IOP and GMs were significantly lower than pre-op (p<0.05), but there was no significant difference in VA. Complete success was achieved in 3 patients (25%) and qualified success was achieved in 6 patients (50%). At POM6 (n=6), complete success was achieved in 1 patient (17%) and qualified success in 4 patients (67%).
XEN Gel stent implantation was successful in the short term for reducing IOP and number of medications in patients with refractory open angle glaucoma; however, further investigation with a larger sample size is necessary to understand long-term outcomes.
This is a 2020 ARVO Annual Meeting abstract.
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