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Dominika Pohlmann, Jan Henrik Terheyden, Moritz Berger, Giovanni Ometto, Giovanni Montesano, Felicitas Neuber, Maximilian W.M. Wintergerst, Tariq Aslam, Xiaoxuan Liu, Frank G Holz, Pearse Andrew Keane, David P. Crabb, Alastair K Denniston, Robert Finger, Uwe Pleyer; OCT-based automated vitreous inflammation score: a promising biomarker in dexamethasone implant treated uveitis patients. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3245.
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© ARVO (1962-2015); The Authors (2016-present)
To objectively detect and evaluate vitreous inflammation before and after dexamethasone implant in patients with uveitis by using a recently developed optical coherence tomography (OCT)-based algorithm.
In this multicenter, retrospective, cross-sectional study, 302 eyes of 223 uveitis patients were included. Clinical and OCT data (Spectralis; Heidelberg Engineering Inc) of all patients were collected. The inflammation score was obtained using an available automated OCT-based algorithm.1 Data of pre and post dexamethasone implantation were compared using a random effects model.1Montesano, G., Way, C. M., Ometto, G., Ibrahim, H., Jones, P. R., Carmichael, R., Liu, X., Aslam, T., Keane, P. A., Crabb, D. P. & Denniston, A. K. (2018). Optimizing OCT acquisition parameters for assessments of vitreous haze for application in uveitis. Scientific Reports, 8, 1648. doi: 10.1038/s41598-018-20092-y
Patients with cystoid macular edema in uveitis anterior (n=18 eyes), intermediate (n=106 eyes), posterior (n=153 eyes), and panuveitis (n=25 eyes) were treated with a dexamethasone implant. The mean of age was 61 years +/- 15 years and a range of 22 to 88 years. We registered 277 follow-up visits at 1 month (up to 2 months after injection) and 265 follow-up visits at 3 months (>2 months to 4 months). The mean inflammation score at baseline was 0.135, and changed significantly to 0.077 (p<0.0001) 1-2 months and to 0.079 (p<0.0001) 3 months after dexamethasone injection. Correlations with clinical ratings of intraocular inflammation are currently evaluated.
Automated OCT-based objective quantification of vitreous inflammation captures the expected decrease in vitreous inflammation following intravitreal dexamethasone implant. Thus, the automated OCT-based quantification of vitreous inflammation may be a promising alternative and a potentially relevant biomarker compared to current subjective clinical estimates of vitreous inflammation in uveitis.
This is a 2020 ARVO Annual Meeting abstract.
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