June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Significance of External Limiting Membrane Integrity as an OCT Biomarker on Functional Outcomes in Eyes with Macular Edema
Author Affiliations & Notes
  • Huy Vu Nguyen
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Muhammad Hassan
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Khalid Yusuf
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Maria Soledad Ormaechea
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Gunay Uludag
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Muhammad Sohail Halim
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Rubbia Afridi
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Nam Nguyen
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Erin Vigil
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Yasir Jamal Sepah
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Quan Dong Nguyen
    Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, United States
  • Footnotes
    Commercial Relationships   Huy Nguyen, None; Muhammad Hassan, None; Khalid Yusuf, None; Maria Ormaechea, None; Gunay Uludag, None; Muhammad Halim, None; Rubbia Afridi, None; Nam Nguyen, None; Erin Vigil, None; Yasir Jamal Sepah, None; Quan Nguyen, None
  • Footnotes
    Support  Heed Ophthalmic Foundation
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3250. doi:
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      Huy Vu Nguyen, Muhammad Hassan, Khalid Yusuf, Maria Soledad Ormaechea, Gunay Uludag, Muhammad Sohail Halim, Rubbia Afridi, Nam Nguyen, Erin Vigil, Yasir Jamal Sepah, Quan Dong Nguyen; Significance of External Limiting Membrane Integrity as an OCT Biomarker on Functional Outcomes in Eyes with Macular Edema. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3250.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate effect of foveal external limiting membrane (ELM) disruption detected using Optical Coherence Tomography (OCT) on visual outcomes of eyes with resolved macular edema.

Methods : Patients with macular edema were randomized 1:1 to receive 0.5 or 2.0 mg of monthly IVT ranibizumab until month 6, followed by PRN dosing (READ-3 Study). In this analysis, patients were divided based on presence of intact (G1) or disrupted (G2) ELM at month 12. Mean change in visual acuity (VA) and percentage of patients achieving greater or equal to 2 lines of improvement were compared.

Results : Of 152 eyes included in READ-3 study, 18 eyes (G1=12 and G2=6) with resolved edema and good quality OCT scans were analyzed. The mean change in VA in G1 was significantly better compared to G2 (15.8 vs 3.7 letters, p=0.006). 75% (G1) compared to 16% (G2) of eyes showed ≥2 lines improvement (p=0.019).

Conclusions : ELM integrity appears to be an important factor determining visual outcome in patients with macular edema.

This is a 2020 ARVO Annual Meeting abstract.

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