June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Real world outcomes for aflibercept in diabetic macula edema
Author Affiliations & Notes
  • Haralabos Eleftheriadis
    Ophthalmology, King's College Hospital NHS Foundation Trust, London, Brixton, United Kingdom
  • Irene Mary Stratton
    Cheltenham General Hospital, United Kingdom
  • James S Talks
    Royal Victoria Hospital, United Kingdom
  • Peter Henry Scanlon
    Cheltenham General Hospital, United Kingdom
  • Shahram Kashani
    East Sussex Healthcare NHS Trust, United Kingdom
  • Andrew J Lotery
    University Hospital Southampton, United Kingdom
  • Clare Bailey
    Bristol Eye Hospital, United Kingdom
  • Raj Mukherjee
    Leeds Teaching Hospitals NHS Trust, United Kingdom
  • Usha Chakravarthy
    Queen's University Belfast, United Kingdom
  • Footnotes
    Commercial Relationships   Haralabos Eleftheriadis, Bayer (F); Irene Stratton, Bayer (F); James Talks, Bayer (F); Peter Scanlon, Bayer (F); Shahram Kashani, Bayer (F); Andrew Lotery, Bayer (F); Clare Bailey, Bayer (F); Raj Mukherjee, Bayer (F); Usha Chakravarthy, Bayer (F)
  • Footnotes
    Support  Bayer financial support with data collection and analysis
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3290. doi:
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      Haralabos Eleftheriadis, Irene Mary Stratton, James S Talks, Peter Henry Scanlon, Shahram Kashani, Andrew J Lotery, Clare Bailey, Raj Mukherjee, Usha Chakravarthy; Real world outcomes for aflibercept in diabetic macula edema. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3290.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Aflibercept was licensed in UK for use as treatment for diabetic macula edema (DME) in 2015. Here we report on real life experience in 21 UK hospitals in first eyes treated with aflibercept and followed for at least 12 months.

Methods : Data were exported from a dedicated ophthalmology electronic patient record system. Those who had aflibercept injections only were included. For those who had both eyes treated for DME, the first eye to be treated was included and for those who had both eyes first treated on the same day, the better eye was included. Linear regression was used to examine the relationship of change in letter score with age, baseline letter score and number of injections. Age groups were defined as <65, 65 to 74, 75 years and above. Baseline letter scores were grouped <60, 60 to 69, 70 to 79, 80 or more.

Results : Data for 1160 people who could have had at least 12 months follow-up from first injection were available. They were age 66 (56 to 73) (median (25th to 75th centile), the baseline letter count was 64 (54 to 73) and they had received 6 (5 to 8) injections. Over 12 months, the improvement in letter score was 5 (0 to 12).
In linear regression analysis, those with worse vision at baseline had greater improvement (p<0.001), those with fewer than 50 letters at baseline gaining 19 letters more than those with 80 or more. Older people had smaller improvement (p<0.001), those under 65 years gaining 5 more letters than those 75 years of age or older.
Each injection gave an improvement from baseline of 0.5 (0.2) (estimate (standard error)) letters (p=0.005).

Conclusions : Age at baseline and initial letter score have greatest impact on vision measured at 12 months and each injection gives a significant improvement in vision.

This is a 2020 ARVO Annual Meeting abstract.

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