June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Carotid stiffness is associated with retinal microvascular dysfunction– The Maastricht Study
Author Affiliations & Notes
  • Frank Cornelis Theodorus van der Heide
    Department of Internal Medicine, University of Maastricht, Maastricht, Netherlands
    CARIM School for Cardiovascular Diseases, University of Maastricht, Maastricht, Netherlands
  • Tan Lai Zhou
    Department of Internal Medicine, University of Maastricht, Maastricht, Netherlands
    CARIM School for Cardiovascular Diseases, University of Maastricht, Maastricht, Netherlands
  • Ronald Henry
    Department of Internal Medicine, University of Maastricht, Maastricht, Netherlands
    CARIM School for Cardiovascular Diseases, University of Maastricht, Maastricht, Netherlands
  • Alfons Houben
    Department of Internal Medicine, University of Maastricht, Maastricht, Netherlands
    CARIM School for Cardiovascular Diseases, University of Maastricht, Maastricht, Netherlands
  • Abraham Kroon
    Department of Internal Medicine, University of Maastricht, Maastricht, Netherlands
    CARIM School for Cardiovascular Diseases, University of Maastricht, Maastricht, Netherlands
  • Carla van der Kallen
    Department of Internal Medicine, University of Maastricht, Maastricht, Netherlands
    CARIM School for Cardiovascular Diseases, University of Maastricht, Maastricht, Netherlands
  • Pieter Dagnelie
    Department of Internal Medicine, University of Maastricht, Maastricht, Netherlands
    CARIM School for Cardiovascular Diseases, University of Maastricht, Maastricht, Netherlands
  • Martien van Dongen
    CAPHRI Care and Public Health Research Institute, University of Maastricht, Maastricht, Netherlands
    Department of Epidemiology, University of Maastricht, Maastricht, Netherlands
  • Simone Eussen
    CARIM School for Cardiovascular Diseases, University of Maastricht, Maastricht, Netherlands
    Department of Epidemiology, University of Maastricht, Maastricht, Netherlands
  • Tos TJM Berendschot
    University Eye Clinic Maastricht, Maastricht University Medical Centre+, Netherlands
  • Jan Schouten
    University Eye Clinic Maastricht, Maastricht University Medical Centre+, Netherlands
    Department of Opthalmology, Canisius Wilhelmina Hospital Nijmegen, Maastricht, Netherlands
  • Carroll Webers
    University Eye Clinic Maastricht, Maastricht University Medical Centre+, Netherlands
  • Miranda Schram
    Department of Internal Medicine, University of Maastricht, Maastricht, Netherlands
    CARIM School for Cardiovascular Diseases, University of Maastricht, Maastricht, Netherlands
  • Marleen van Greevenbroek
    Department of Internal Medicine, University of Maastricht, Maastricht, Netherlands
    CARIM School for Cardiovascular Diseases, University of Maastricht, Maastricht, Netherlands
  • Koen Reesink
    CARIM School for Cardiovascular Diseases, University of Maastricht, Maastricht, Netherlands
    Department of Biomedical Engineering, University of Maastricht, Maastricht, Netherlands
  • Coen DA Stehouwer
    Department of Internal Medicine, University of Maastricht, Maastricht, Netherlands
    CARIM School for Cardiovascular Diseases, University of Maastricht, Maastricht, Netherlands
  • Footnotes
    Commercial Relationships   Frank van der Heide, None; Tan Lai Zhou, None; Ronald Henry, None; Alfons Houben, None; Abraham Kroon, None; Carla van der Kallen, None; Pieter Dagnelie, None; Martien van Dongen, None; Simone Eussen, None; Tos TJM Berendschot, None; Jan Schouten, None; Carroll Webers, None; Miranda Schram, None; Marleen van Greevenbroek, None; Koen Reesink, None; Coen Stehouwer, None
  • Footnotes
    Support  European Regional Development Fund via OP-Zuid, the Province of Limburg, the Dutch Ministry of Economic Affairs (grant 31O.041), Stichting De Weijerhorst (Maastricht, the Netherlands), the Pearl String Initiative Diabetes (Amsterdam, the Netherlands), the Cardiovascular Center (CVC, Maastricht, the Netherlands), CARIM School for Cardiovascular Diseases (Maastricht, the Netherlands), CAPHRI School for Public Health and Primary Care (Maastricht, the Netherlands), NUTRIM School for Nutrition and Translational Research in Metabolism (Maastricht, the Netherlands), Stichting Annadal (Maastricht, the Netherlands), Health Foundation Limburg (Maastricht, the Netherlands), Perimed (Järfälla, Sweden), Diabetesfonds (Amersfoort, The Netherlands), Oogfonds (Utrecht, The Netherlands) and by unrestricted grants from Janssen-Cilag B.V. (Tilburg, the Netherlands), Novo Nordisk Farma B.V. (Alphen aan den Rijn, the Netherlands), and Sanofi-Aventis Netherlands B.V. (Gouda, the Netherlands).
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3323. doi:
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      Frank Cornelis Theodorus van der Heide, Tan Lai Zhou, Ronald Henry, Alfons Houben, Abraham Kroon, Carla van der Kallen, Pieter Dagnelie, Martien van Dongen, Simone Eussen, Tos TJM Berendschot, Jan Schouten, Carroll Webers, Miranda Schram, Marleen van Greevenbroek, Koen Reesink, Coen DA Stehouwer; Carotid stiffness is associated with retinal microvascular dysfunction– The Maastricht Study. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3323.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Diabetic retinopathy is one of the leading causes of blindness and is preceded by impaired microvascular autoregulation. However, potential treatment targets for these early changes are still unknown. We hypothesized that arterial stiffness, measured by aortic and carotid stiffness, may be such a target and therefore investigated the association between arterial stiffness and retinal microvascular function.

Methods : We used cross-sectional data from the Maastricht Study, a type 2 diabetes-enriched population-based cohort study (n=1,838 [51% men, mean age 59.9±8.2 years, 14.9% prediabetes, 28.4%T2D]). We standardized carotid and aortic stiffness (i.e. carotid distensibility coefficient [DC] and carotid-femoral pulse wave velocity [cfPWV]), retinal vascular dilatation response and caliber measures. We investigated associations with linear regression and adjusted for age, sex, glucose metabolism status, mean arterial pressure, heart rate, waist circumference, lipid profile, the use of lipid-modifying and blood pressure-lowering medication, smoking and alcohol consumption. In addition, we tested whether these associations were modified by sex or type 2 diabetes.

Results : After adjustment, lower carotid DC (per SD) was significantly associated with lower retinal arteriolar microvascular dilatation (SD) (-0.06 [95%CI -0.12; 0.00]), but not significantly with venular microvascular dilatation (-0.04 [-0.10; 0.02]). In addition, these associations were stronger in men and in T2D. In contrast, cfPWV was not associated with microvascular dilatation and neither carotid DC nor cfPWV were associated with CRAE or CRVE.

Conclusions : Greater carotid stiffness is associated with retinal microvascular dysfunction. Hence, carotid stiffness may be a determinant of retinal microvascular dysfunction and early diabetic retinopathy.

This is a 2020 ARVO Annual Meeting abstract.

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