June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Quantitative analysis of glare symptom in patients with Fuchs endothelial corneal dystrophy
Author Affiliations & Notes
  • Atsushi Watanabe
    The Department of Ophthalmology, Osaka University Graduate School of Medicine, Japan
    Yodogawa Christian Hospital, Japan
  • Yoshinori Oie
    The Department of Ophthalmology, Osaka University Graduate School of Medicine, Japan
  • Suzuka Maeda
    The Department of Ophthalmology, Osaka University Graduate School of Medicine, Japan
  • Nozomi Nishida
    The Department of Ophthalmology, Osaka University Graduate School of Medicine, Japan
  • Sanae Asonuma
    The Department of Ophthalmology, Osaka University Graduate School of Medicine, Japan
  • Chihomi Fujimoto
    The Department of Ophthalmology, Osaka University Graduate School of Medicine, Japan
  • Ryo Kawasaki
    The Department of Ophthalmology, Osaka University Graduate School of Medicine, Japan
  • Naoyuki Maeda
    The Department of Ophthalmology, Osaka University Graduate School of Medicine, Japan
    Kozaki Eye Clinic, Japan
  • Kohji Nishida
    The Department of Ophthalmology, Osaka University Graduate School of Medicine, Japan
    Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary ResearchInitiatives (OTRI), Japan
  • Footnotes
    Commercial Relationships   Atsushi Watanabe, None; Yoshinori Oie, None; Suzuka Maeda, None; Nozomi Nishida, None; Sanae Asonuma, None; Chihomi Fujimoto, None; Ryo Kawasaki, None; Naoyuki Maeda, TOMEY CORPORATION (R); Kohji Nishida, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3332. doi:
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    • Get Citation

      Atsushi Watanabe, Yoshinori Oie, Suzuka Maeda, Nozomi Nishida, Sanae Asonuma, Chihomi Fujimoto, Ryo Kawasaki, Naoyuki Maeda, Kohji Nishida; Quantitative analysis of glare symptom in patients with Fuchs endothelial corneal dystrophy. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3332.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To quantitatively analyze glare symptom in patients with Fuchs endothelial corneal dystrophy (FECD).

Methods : Nineteen eyes of 19 patients with FECD were recruited at the outpatient clinic of the Department of Ophthalmology at Osaka University Hospital. The mean age was 64±13 years. Three males and 16 females were included. The mean central corneal thickness (CCT) was 604±57um. Patients with nuclear cataract of grade 3 or more were excluded. Visual analog scale (VAS) was used to evaluate the severity of glare symptom outside in the daytime, by head lights of cars outside at night, and by television or computer monitor inside. We divided the patients into two groups if they feel glare sympotom, and compared distance corrected visual acuity (CDVA), the area under log contrast sensitivity function (AULCSF) calculated from the obtained contrast sensitivity data, pupil diameter, forward light scattering, backward light scattering, and higher order aberrations for the two groups.

Results : Median VAS scores were 2.5 outdoors in the daytime, 4.0 by head light of cars at night, and 1.9 by television or computer monitors indoors. There was a significant difference between the three conditions (p=0.0054), and the difference was significant between that at night than in the other two conditions. Nine patients felt glare (glare group), while 10 patients did not feel (no glare group). Glare group had significantly lower AULCSF (8.1±2.0 vs. 14.8±1.9 log, p=0.0242), increased forward light scattering (1.56±0.06 vs. 1.31±0.06 log(s) p=0.0114), and thicker CCT (633±17 vs. 578±16 um, p=0.0326) than no glare group. There was no significant difference between the two groups in CDVA, pupil diameter, backward light scattering, and higher order aberrations.

Conclusions : Patients with FECD had stronger glare symptom by head lights of cars outside at night. In addition, patients with severer FECD had stronger glare symptom and lower contrast sensitivity presumably because of increased forward light scattering.

This is a 2020 ARVO Annual Meeting abstract.

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