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Giedre Pakuliene, Loreta Kuzmiene, Brent A Siesky, Alon Harris, Ingrida Januleviciene; Aqueous Humour Flare in Cataract Patients with or without Glaucoma. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3426.
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© ARVO (1962-2015); The Authors (2016-present)
The purpose of this study was to evaluate ocular aqueous humour flare in cataract patients with or without open angle glaucoma.
A prospective case-control age and gender matched study with a case-control ratio 2:1. The Kaunas Regional Biomedical Ethics Committee approved all study procedures and participants signed an informed consent. The open angle glaucoma group (treated for >2 years) with cataract was matched to the control group of cataract patients with no other ocular pathology. Inclusion criteria: IOP <21.0mmHg, no ocular hyperemia or medication intolerance. Methods included full ophthalmic evaluation, Goldmann applanation tonometry for intraocular pressure (IOP), and ocular aqueous humour laser flare and cell photometry (Kowa FM-700 ver. 2.01.200000, Japan). Flare count was presented as photon count per millisecond (pc/ms). We additionally analyzed groups divided by presence of pseudoexfoliation syndrome (PEX). Statistical analysis was performed with SPSS v23.0 program package.
The glaucoma group included 22 subjects with 44 subjects in control group. Male/female ratio was 32/68%, age mean (SE) was 74.7 (8.9) in glaucoma group and 72.6 (8.2) in the control group. The aqueous humour flare mean (SE) in the glaucoma group was 18.9 (2.2) pc/ms, median 17.3 pc/ms and 10.0 (0.76) pc/ms, median was 9.2 pc/ms in the control group (p<0.001, Mann-Whitney U test). There was no significant correlation between IOP and flare (p>0.05, PCC). PEX was found in 10 glaucoma and 9 control subjects. Aqueous humour flare mean (SE) in glaucoma (PEX+) group was 18.7(2.8) pc/ms, median 17.8 pc/ms while in control (PEX+) was 14.8 (2.3) pc/ms, median 13.5 pc/ms, (p=0.234, Mann-Whitney U test). Aqueous humour flare mean (SE) in glaucoma group (PEX-) mean (SE) was 19.0 (3.4) pc/ms, median 17.0 pc/ms and 8.6 (0.7) pc/ms, median 7.6 pc/ms in control (PEX-) (p<0.001, Mann-Whitney U test).
Aqueous humour flare was higher in glaucoma patients with cataract compared to non-glaucomatous cataract patients. The presence of PEX increased the mean flare in controls, however a similar trend occurred in glaucoma patients with PEX.
This is a 2020 ARVO Annual Meeting abstract.
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