June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Aqueous Humour Flare in Cataract Patients with or without Glaucoma
Author Affiliations & Notes
  • Giedre Pakuliene
    Ophthalmology Department, Lithuanian University of Health Sciences , Kaunas, Lithuania
  • Loreta Kuzmiene
    Ophthalmology Department, Lithuanian University of Health Sciences , Kaunas, Lithuania
  • Brent A Siesky
    Icahn School of Medicine, Mount Sinai Hospital, New York, New York, United States
  • Alon Harris
    Icahn School of Medicine, Mount Sinai Hospital, New York, New York, United States
  • Ingrida Januleviciene
    Ophthalmology Department, Lithuanian University of Health Sciences , Kaunas, Lithuania
  • Footnotes
    Commercial Relationships   Giedre Pakuliene, None; Loreta Kuzmiene, None; Brent Siesky, None; Alon Harris, AdOM (C), AdOM (I), AdOM (S), AdOM (R), LuSeed (I), Oxymap (I), Thea (R); Ingrida Januleviciene, Novartis (C), Origmed (C), Santen (F), Santen (C), Thea (C), Vittamed (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3426. doi:
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      Giedre Pakuliene, Loreta Kuzmiene, Brent A Siesky, Alon Harris, Ingrida Januleviciene; Aqueous Humour Flare in Cataract Patients with or without Glaucoma. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3426.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The purpose of this study was to evaluate ocular aqueous humour flare in cataract patients with or without open angle glaucoma.

Methods : A prospective case-control age and gender matched study with a case-control ratio 2:1. The Kaunas Regional Biomedical Ethics Committee approved all study procedures and participants signed an informed consent. The open angle glaucoma group (treated for >2 years) with cataract was matched to the control group of cataract patients with no other ocular pathology. Inclusion criteria: IOP <21.0mmHg, no ocular hyperemia or medication intolerance. Methods included full ophthalmic evaluation, Goldmann applanation tonometry for intraocular pressure (IOP), and ocular aqueous humour laser flare and cell photometry (Kowa FM-700 ver. 2.01.200000, Japan). Flare count was presented as photon count per millisecond (pc/ms). We additionally analyzed groups divided by presence of pseudoexfoliation syndrome (PEX). Statistical analysis was performed with SPSS v23.0 program package.

Results : The glaucoma group included 22 subjects with 44 subjects in control group. Male/female ratio was 32/68%, age mean (SE) was 74.7 (8.9) in glaucoma group and 72.6 (8.2) in the control group. The aqueous humour flare mean (SE) in the glaucoma group was 18.9 (2.2) pc/ms, median 17.3 pc/ms and 10.0 (0.76) pc/ms, median was 9.2 pc/ms in the control group (p<0.001, Mann-Whitney U test). There was no significant correlation between IOP and flare (p>0.05, PCC). PEX was found in 10 glaucoma and 9 control subjects. Aqueous humour flare mean (SE) in glaucoma (PEX+) group was 18.7(2.8) pc/ms, median 17.8 pc/ms while in control (PEX+) was 14.8 (2.3) pc/ms, median 13.5 pc/ms, (p=0.234, Mann-Whitney U test). Aqueous humour flare mean (SE) in glaucoma group (PEX-) mean (SE) was 19.0 (3.4) pc/ms, median 17.0 pc/ms and 8.6 (0.7) pc/ms, median 7.6 pc/ms in control (PEX-) (p<0.001, Mann-Whitney U test).

Conclusions : Aqueous humour flare was higher in glaucoma patients with cataract compared to non-glaucomatous cataract patients. The presence of PEX increased the mean flare in controls, however a similar trend occurred in glaucoma patients with PEX.

This is a 2020 ARVO Annual Meeting abstract.

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