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Hyun Goo Kang, Minha Kim, Christopher Seungkyu Lee, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Min Kim; Clinical spectrum of choroidal metastasis in Korean patients based on primary tumor origin. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3644.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate patients with choroidal metastasis based on primary tumor site in Korean patients.
Retrospective case series of consecutive patients diagnosed at 2 tertiary referral-based centers from November 2005 to November 2019. Clinical features and outcomes were evaluated based on the primary tumor site.
There were 128 choroidal metastases diagnosed in 95 eyes of 80 patients. The mean age at diagnosis was 56.4 years (median 56.5, range 24-86), with a minor female preponderance (61%). The tumors were unilateral in 65 (81%) patients and the primary origin had been established in 50 (63%) prior to the detection of choroidal metastases. The primary tumor originated in the lung (48%), breast (24%), gastrointestinal (GI) tract (10%), liver (3%), pancreas (3%), kidney (1%), cervix (1%), and nasopharynx (1%), with a small percentage remaining unknown even after extensive evaluation (10%). The demographics and clinical features of the top 3 most common primary sites (lung, breast, and GI tract) were further analyzed: mean age at diagnosis of choroidal metastasis was 56, 52, and 68 years respectively, and were unilateral in 79%, 79%, and 100% of cases with a mean number of metastasis per eye of 1.2, 1.4, and 1.5. Female preponderance was noted in the lung- and breast-cancer groups (58% and 100%, respectively), but not in the GI tract-cancer group (12.5%). The largest tumor in any 1 eye was evaluated for comparison: choroidal metastasis measured a mean base of 9.4, 10.4, and 5.3 mm respectively, with a mean thickness of 3.2, 3.5 and 5.2 mm, demonstrating a predominantly yellow color in 85%, 87%, and 88% of cases. Of the 65 (81%) patients with documented follow-up, the mean patient survival was 19.2, 22.4, and 38.2 months; Kaplan-Meier analysis revealed a 3-year survival of 22%, 14% and 33% respectively, and a 5-year survival of 6%, 7%, and 17%. The worst survival was found in patients with liver cancer (mean 0.2 months), and the best survival with GI tract cancers (17% at 5 years).
The primary tumor origin in Korea patients differs from those reported in primarily Caucasian population-based studies, with a much higher prevalence of lung and GI tract cancers. Overall prognosis is poor with a 5-year survival rate of 7%.
This is a 2020 ARVO Annual Meeting abstract.
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