June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Drusenoid Lesions in Membrane Metalloendopeptidase Mutant Mice as a Model of Age-Related Macular Degeneration
Author Affiliations & Notes
  • Daniella Lent-Schochet
    Ophthalmology and Vision Science, University of California Davis, Sacramento, California, United States
    College of Medicine, California Northstate University, Sacramento , California, United States
  • Therlinder Lo
    Ophthalmology and Vision Science, University of California Davis, Sacramento, California, United States
    Reno School of Medicine, University of Nevada, Reno, Nevada, United States
  • Andrea Minella
    Veterinary Medicine, University of California Davis, Davis, California, United States
  • Antonio Lopez
    Ophthalmology and Vision Science, University of California Davis, Sacramento, California, United States
  • Sara M Thomasy
    Veterinary Medicine, University of California Davis, Davis, California, United States
  • Christopher Murphy
    Veterinary Medicine, University of California Davis, Davis, California, United States
  • Ala Moshiri
    Ophthalmology and Vision Science, University of California Davis, Sacramento, California, United States
  • Glenn Yiu
    Ophthalmology and Vision Science, University of California Davis, Sacramento, California, United States
  • Footnotes
    Commercial Relationships   Daniella Lent-Schochet, None; Therlinder Lo, None; Andrea Minella, None; Antonio Lopez, None; Sara Thomasy, None; Christopher Murphy, EyeKor Inc (I), Ocular Services in Demand (I); Ala Moshiri, None; Glenn Yiu, Alcon (F), Alimera (C), Allergan (C), Carl Zeiss Meditec (C), Clearside Biomedical (F), Genentech (F), Genentech (C), Iridex (F), Iridex (C)
  • Footnotes
    Support  NIH Grant K08 EY026101 and NIH Grant R21 EY031108
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3684. doi:
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      Daniella Lent-Schochet, Therlinder Lo, Andrea Minella, Antonio Lopez, Sara M Thomasy, Christopher Murphy, Ala Moshiri, Glenn Yiu; Drusenoid Lesions in Membrane Metalloendopeptidase Mutant Mice as a Model of Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3684.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly, but there are few animal models of drusen as seen in non-exudative AMD. In this study, we evaluate drusenoid lesions in matrix metalloendopeptidase (MME) gene knock-out mice as a potential model of AMD.

Methods : C57BL/6 mice with MME (-/-) gene knock-out and drusen-like lesions were identified during phenotypic screening as part of the Mouse Biology Program at UC Davis. Full ophthalmic examination, fundus photography, fluorescein angiography (FA), optical coherence tomography (OCT) imaging, and electroretinographic (ERG) testing were performed.

Results : MME -/- mice had pale yellow circular lesions on fundus examination, which appeared hyperfluorescent on FA. On OCT, these dome-shaped lesions appear to be located underneath the retinal pigment epithelium (RPE) with associated disruption of overlying retinal layers, similar in appearance to soft drusen in human AMD. Full-field electroretinography shows overall normal retinal function in eyes with these lesions.

Conclusions : Retinal lesions in the MME -/- mutant mice may resemble soft drusen in eyes with AMD. Further characterization of this mutant mouse model may provide insight into drusen biogenesis and the pathogenesis of AMD.

This is a 2020 ARVO Annual Meeting abstract.

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