June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Associations between retinal artery occlusions and cardiovascular disorders: a nationwide, registry-based, case-control study.
Author Affiliations & Notes
  • Jakob Grauslund
    Ophthalmology, Odense University Hospital, Odense, Denmark
  • Lonny Merete Stokholm
    University of Southern Denmark, Odense, Denmark
  • Katrine Hartmund Frederiksen
    Ophthalmology, Odense University Hospital, Odense, Denmark
  • Peter Hartmund Frederiksen
    University of Southern Denmark, Odense, Denmark
  • Gerda Møller
    Ophthalmology, Odense University Hospital, Odense, Denmark
  • Kirsten Kyvik
    University of Southern Denmark, Odense, Denmark
  • Morten de la Cour
    University of Copenhagen, Copenhagen, Denmark
  • Line Kessel
    University of Copenhagen, Copenhagen, Denmark
  • Katrine Hass Rubin
    University of Southern Denmark, Odense, Denmark
  • Christina Jørgensen
    Ophthalmology, Odense University Hospital, Odense, Denmark
  • Footnotes
    Commercial Relationships   Jakob Grauslund, None; Lonny Stokholm, None; Katrine Frederiksen, None; Peter Frederiksen, None; Gerda Møller, None; Kirsten Kyvik, None; Morten de la Cour, None; Line Kessel, None; Katrine Rubin, None; Christina Jørgensen, None
  • Footnotes
    Support  Research grant from Odense University Hospital and Rigshospitalet
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3852. doi:
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      Jakob Grauslund, Lonny Merete Stokholm, Katrine Hartmund Frederiksen, Peter Hartmund Frederiksen, Gerda Møller, Kirsten Kyvik, Morten de la Cour, Line Kessel, Katrine Hass Rubin, Christina Jørgensen; Associations between retinal artery occlusions and cardiovascular disorders: a nationwide, registry-based, case-control study.. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3852.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The purpose of the study was to evaluate the association between occurrence of retinal artery occlusion (RAO) and the risk of subsequent cardiovascular disorders (CVD) in a real-life, national cohort from Denmark.

Methods : A nationwide, population-based, case-control study using the Danish National Patient Registry was conducted of all patients in Denmark, who received a diagnosis of RAO from any Danish ophthalmology clinic between January 1, 1998, and December 31, 2018. Patients and controls were not allowed any record of previous RAO or CVD before January 1, 1998. Cardiovascular disorders were sorted into three groups: ischemic CVD, non-ischemic CVD and potentially embolizing disorders. For each patient, ten age- and sex-matched controls were included. All patients were followed from the date of RAO-diagnosis (or corresponding entry date for the controls) until the earliest CVD diagnosis, death, emigration, or December 31, 2018, whichever occurred first. A Cox proportional hazards model was used to calculate hazard ratios (HR) with 95% confidence intervals (CI) for the associations between RAO and CVD using days from date of first registration of RAO as the underlying time scale.

Results : The results include 2787 RAO patients, comprising 1203 (43.2%) with central RAO (CRAO), 371 (13.3%) with branch RAO (BRAO) and 1213 (43.5%) with anatomically unspecified RAO. At baseline, 49.1 % were males, and mean age was 66.9±14.1 years. Where affected eye was specified (n=1495), 50.8% were right eye, 46.3% were left eye and 2.9% were bilateral.
HRs for subsequent development of CVD among all RAO patients were 2.53 (2.35-2.73) for ischemic CVD, 2.11 (1.99-2.24) for non-ischemic CVD and 1.41 (1.27-1.57) for potentially embolizing disorders. Results were similar in a subgroup analysis of CRAO and BRAO. Among potentially embolizing disorders, there was an increased HR for subsequent development of atrial fibrillation (1.40, 1.26-1.56) and endocarditis (1.97, 1.11-3.48). In a subgroup analysis of CRAO and BRAO, results were similar in CRAO, but no increased HR was found in BRAO.

Conclusions : In a real-life, national cohort, we found an increased risk for subsequent development of ischemic CVD, non-ischemic CVD and potentially embolizing disorders for patients diagnosed with retinal artery occlusions.

This is a 2020 ARVO Annual Meeting abstract.

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