June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Ocular and Systemic Determinants of Macular Vessel Parameters in Healthy African Americans: the African American Eye Disease Study
Author Affiliations & Notes
  • Grace Marie Richter
    USC Roski Eye Institute, Keck Medicine of University of Southern California, Los Angeles, California, United States
  • Jae Chang Lee
    USC Roski Eye Institute, Keck Medicine of University of Southern California, Los Angeles, California, United States
  • Bruce Burkemper
    USC Roski Eye Institute, Keck Medicine of University of Southern California, Los Angeles, California, United States
  • Farzan Abdolahi
    USC Roski Eye Institute, Keck Medicine of University of Southern California, Los Angeles, California, United States
  • Brennan Hand
    USC Roski Eye Institute, Keck Medicine of University of Southern California, Los Angeles, California, United States
  • Diana Hong
    USC Roski Eye Institute, Keck Medicine of University of Southern California, Los Angeles, California, United States
  • Brenda Ryuna Chang
    USC Roski Eye Institute, Keck Medicine of University of Southern California, Los Angeles, California, United States
  • Zhongdi Chu
    Department of Bioengineering, University of Washington, Seattle, Washington, United States
  • Xiao Zhou
    Department of Bioengineering, University of Washington, Seattle, Washington, United States
  • Ruikang K Wang
    Department of Bioengineering, University of Washington, Seattle, Washington, United States
  • Rohit Varma
    Southern California Eyecare and Vision Research Institute, Los Angeles, California, United States
  • Amir H Kashani
    USC Roski Eye Institute, Keck Medicine of University of Southern California, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Grace Richter, Carl Zeiss Meditec (F); Jae Lee, None; Bruce Burkemper, None; Farzan Abdolahi, None; Brennan Hand, None; Diana Hong, None; Brenda Chang, None; Zhongdi Chu, None; Xiao Zhou, None; Ruikang Wang, Carl Zeiss Meditec (F), Carl Zeiss Meditec (P), Carl Zeiss Meditec (C); Rohit Varma, None; Amir Kashani, Carl Zeiss Meditec (F), Carl Zeiss Meditec (R)
  • Footnotes
    Support  NIH Grant 5K23EY027855-03; NIH Grant U10EY023575;NIH R01EY030564; NIH K08EY027006; Unrestricted Departmental Grant From Research To Prevent Blindness
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3900. doi:
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      Grace Marie Richter, Jae Chang Lee, Bruce Burkemper, Farzan Abdolahi, Brennan Hand, Diana Hong, Brenda Ryuna Chang, Zhongdi Chu, Xiao Zhou, Ruikang K Wang, Rohit Varma, Amir H Kashani; Ocular and Systemic Determinants of Macular Vessel Parameters in Healthy African Americans: the African American Eye Disease Study. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3900.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the ocular and systemic determinants of macular vessel parameters in healthy eyes in the African American Eye Disease Study population.

Methods : 3x3mm macula spectral-domain optical coherence tomography angiography (OCT-A; CIRRUS 5000 HD-OCT with AngioPlex; ZEISS, Dublin, CA, USA) scans were performed on participants of the African American Eye Disease Study (AFEDS), which consisted of African Americans 40 years and older in Inglewood, California. Subjects with glaucoma, severe non-proliferative diabetic retinopathy (NPDR), PDR, and macular edema were excluded. Custom software quantified vessel area density (VAD), vessel skeleton density (VSD), and vessel diameter index (VDI) in the superficial retinal layer (SRL) of the macula. A multivariable linear regression model controlling for inter-eye correlation was used to identify the ocular and systemic factors associated with each OCTA parameter with a significance level set at 0.05. Candidate variables included: central corneal thickness (CCT), VF mean deviation (MD), intraocular pressure (IOP), axial length (AL), signal strength (SS), mean ocular perfusion pressure (MOPP), body mass index, age, gender, systolic blood pressure (BP), diastolic BP, pulse pressure (PP), mean arterial pressure (MAP), history of smoking, history of diabetes, diabetes duration, and history of stroke or brain hemorrhage (SB).

Results : Of 797 OCTA imaged eyes from 627 subjects with good quality images, 737 eyes met inclusion and exclusion criteria. The multivariable model for VAD included: SS (β= 0.0085, p<0.0001), PP (β= -0.0001, p=0.019), and SB (β= -0.008, p=0.0004), controlling for AL (β= -0.0013, p=0.101) and age (β= -0.0001, p=0.118). The multivariable model for VSD included: AL (β= 0.0008, p=0.006), SS (β= 0.002, p<0.0001), PP (β= -0.00004, p=0.027), SB (β= -0.003, p=0.019), and age (β= -0.0001, p=0.017). The multivariable model for VDI included: AL (β= -0.026, p< 0.0001), SS (β= 0.019, p< 0.0001), age (β= 0.0009, p=0.0004), female gender (β= -0.0232, p<0.0001), MAP (β= -0.0006, p=0.0001), and diabetes duration (β= 0.0012 p=0.012).

Conclusions : Older age, longer AL, lower SS, and systemic variables including wider PP and SB were independently associated with reduced VAD or VSD. The effect of these variables need to be considered when evaluating the macular microcirculation on OCTA in the clinical setting.

This is a 2020 ARVO Annual Meeting abstract.

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