June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Optic disc characteristics of glaucoma eyes with and without high myopia
Author Affiliations & Notes
  • Jasmin Rezapour
    Viterbi Family Department of Ophthalmology, University of California, San Diego, Hamilton Glaucoma Center, Shiley Eye Institute, San Diego, California, United States
    Ophthalmology, University Medical Center Mainz, Mainz, Germany
  • James Alexander Proudfoot
    Viterbi Family Department of Ophthalmology, University of California, San Diego, Hamilton Glaucoma Center, Shiley Eye Institute, San Diego, California, United States
  • Jade Dohleman
    Viterbi Family Department of Ophthalmology, University of California, San Diego, Hamilton Glaucoma Center, Shiley Eye Institute, San Diego, California, United States
  • Mark Christopher
    Viterbi Family Department of Ophthalmology, University of California, San Diego, Hamilton Glaucoma Center, Shiley Eye Institute, San Diego, California, United States
  • Akram Belghith
    Viterbi Family Department of Ophthalmology, University of California, San Diego, Hamilton Glaucoma Center, Shiley Eye Institute, San Diego, California, United States
  • Leslie Hyman
    Thomas Jefferson University, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Jost Jonas
    Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany
  • Christopher Bowd
    Viterbi Family Department of Ophthalmology, University of California, San Diego, Hamilton Glaucoma Center, Shiley Eye Institute, San Diego, California, United States
  • Ruti Sella
    Ophthalmology, Rabin Medical Center, Israel
    Viterbi Family Department of Ophthalmology, University of California, San Diego, Hamilton Glaucoma Center, Shiley Eye Institute, San Diego, California, United States
  • Natalie A Afshari
    Viterbi Family Department of Ophthalmology, University of California, San Diego, Hamilton Glaucoma Center, Shiley Eye Institute, San Diego, California, United States
  • Huiyuan Hou
    Viterbi Family Department of Ophthalmology, University of California, San Diego, Hamilton Glaucoma Center, Shiley Eye Institute, San Diego, California, United States
  • Sasan Moghimi
    Viterbi Family Department of Ophthalmology, University of California, San Diego, Hamilton Glaucoma Center, Shiley Eye Institute, San Diego, California, United States
  • Rafaella Penteado
    Viterbi Family Department of Ophthalmology, University of California, San Diego, Hamilton Glaucoma Center, Shiley Eye Institute, San Diego, California, United States
  • Robert N Weinreb
    Viterbi Family Department of Ophthalmology, University of California, San Diego, Hamilton Glaucoma Center, Shiley Eye Institute, San Diego, California, United States
  • Linda M Zangwill
    Viterbi Family Department of Ophthalmology, University of California, San Diego, Hamilton Glaucoma Center, Shiley Eye Institute, San Diego, California, United States
  • Footnotes
    Commercial Relationships   Jasmin Rezapour, None; James Proudfoot, None; Jade Dohleman, None; Mark Christopher, None; Akram Belghith, None; Leslie Hyman, None; Jost Jonas, None; Christopher Bowd, None; Ruti Sella, None; Natalie Afshari, None; Huiyuan Hou, None; Sasan Moghimi, None; Rafaella Penteado, None; Robert Weinreb, Aerie Pharmaceuticals (C), Allergan (C), Bausch&Lomb (F), Bausch&Lomb (C), Carl Zeiss Meditec (F), Centervue (F), Eyenovia (C), Heidelberg Engineering GmbH (F), Konan Medical (F), Meditec-Zeiss (P), Optovue (F), Toromedes (P); Linda Zangwill, Carl Zeiss Meditec Inc. (F), Heidelbeg Engineering (R), Heidelberg Engineering GmbH (F), Meditec-Zeiss (P), National Eye Institute (F), Optovue Inc. (F), Topcon Medical Systems Inc. (F)
  • Footnotes
    Support  Jasmin Rezapour: German Research Foundation research fellowship grant recipient (RE 4155/1-1) and German Ophthalmological Society grant, DIGS: EY11008, EY19869, EY14267, EY027510, EY026574, EY029058, P30EY022589, UCSD School of Medicine Summer Research Fellowship, and participant retention incentive grants in the form of glaucoma medication at no cost from Novartis/Alcon Laboratories Inc, Allergan, Akorn, and Pfizer Inc. Unrestricted grant from Research to Prevent Blindness, New York, New York
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3932. doi:
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    • Get Citation

      Jasmin Rezapour, James Alexander Proudfoot, Jade Dohleman, Mark Christopher, Akram Belghith, Leslie Hyman, Jost Jonas, Christopher Bowd, Ruti Sella, Natalie A Afshari, Huiyuan Hou, Sasan Moghimi, Rafaella Penteado, Robert N Weinreb, Linda M Zangwill; Optic disc characteristics of glaucoma eyes with and without high myopia. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3932.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To characterize structural differences in glaucomatous optic discs in eyes with high, low and no myopia using optical coherence tomography (OCT) and OCT angiography (OCTA).

Methods : All glaucoma patients enrolled in the Diagnostic Innovations in Glaucoma Study with axial length (AL), visual field (VF) measurements and good quality Spectralis OCT ONHRC (optic nerve head radial circle) scans for calculation of minimum rim width (MRW) and retinal nerve fiber layer (RNFL) thickness were included. Participants were classified into 3 myopia groups by AL (mm); no (<24), low (24-26) and high (>26) axial myopia. Optic disc ovality index (OI), tilt and torsion were calculated using custom analysis of segmented OCT volumes. AngioVue OCTA ONH whole image vessel density (wiVD) was also analyzed. Linear mixed models were used to compare eye characteristics between groups, and univariable and age and mean deviation (MD) adjusted models were used to evaluate the association between AL and ocular parameters.

Results : 326 glaucoma patients (553 eyes) were classified into 3 groups: no myopia (n=116, VF MD=-6.69 dB), low myopia (n=168, VF MD=-7.1 dB), and high myopia (n=42, VF MD=-8.19 dB) (VF MD differences; p=0.1). Mean (95% CI) OI was significantly lower (more oval) in the high myopia group (0.84 (0.82-0.87)), compared to the low myopia (0.89; (0.87-0.9)) and no myopia group (0.88; (0.87-0.89)) (p=0.01), while disc tilt angle was highest in the high myopia group (9.6° (8.4-10.9)) compared to the no (4.0° (3.3-4.6)) and low myopia group (5.1° (4.5-5.7)) (p<0.001). Disc torsion angle was similar across the 3 groups (22.1°, 22.6°, and 17.7° (p=0.92), respectively) as was mean RNFL thickness (67.0µm, 65.1µm and 64.5µm (p=0.73), respectively). Mean (95% CI) MRW was significantly lower in the high myopia group than in the no- and low-myopia group (170µm (153-188), 198µm (189-208), and 192µm (184-200) respectively, p=0.03)). Mean (95% CI) OCTA wiVD was significantly lower in high myopes (38.1% (36.0-40.2)), compared to low myopes (38.7% (37.7-39.7)), and non-myopes (40.2% (39.0-41.4)) (p=0.01). Disc tilt, wiVD and MRW were significantly associated (all p<0.04) with increasing AL in age, and VF MD adjusted multivariable models.

Conclusions : Caution should be exercised when using ONH MRW and vessel density for glaucoma management decisions in high axial myopia as these global structural parameters are associated with AL.

This is a 2020 ARVO Annual Meeting abstract.

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