June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Impact of different initial systemic staging imaging strategies on metastasis detection in uveal melanoma patients: The Melanoma of the Uvea Staging Imaging Consortium (MUSIC) Study
Author Affiliations & Notes
  • Anthony B Daniels
    Department of Ophthalmology, Vanderbilt Eye Institute, Nashville, Tennessee, United States
    Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States
  • Katherine S. Peters
    Department of Ophthalmology, Vanderbilt Eye Institute, Nashville, Tennessee, United States
    School of Medicine, Vanderbilt University, Nashville, Tennessee, United States
  • Mark P Breazzano
    Department of Ophthalmology, Vanderbilt Eye Institute, Nashville, Tennessee, United States
  • William Choi
    Retina Consultants of Houston, Houston, Texas, United States
  • Jeanette Du
    Ophthalmology, University of Virginia, Virginia, United States
  • Nathan Law
    Casey Eye Institute, Oregon Health Sciences University, Portland, Oregon, United States
  • Audra Miller
    Casey Eye Institute, Oregon Health Sciences University, Portland, Oregon, United States
  • Max Aveis
    Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States
  • Suleyman Ciftci
    Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States
  • Amy C Schefler
    Retina Consultants of Houston, Houston, Texas, United States
  • Hakan Demirci
    Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, United States
  • Alison Skalet
    Casey Eye Institute, Oregon Health Sciences University, Portland, Oregon, United States
  • Yevgeniy Shildkrot
    Ophthalmology, University of Virginia, Virginia, United States
  • Stephen Deppen
    Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States
  • Footnotes
    Commercial Relationships   Anthony Daniels, None; Katherine Peters, None; Mark Breazzano, None; William Choi, None; Jeanette Du, None; Nathan Law, None; Audra Miller, None; Max Aveis, None; Suleyman Ciftci, None; Amy Schefler, None; Hakan Demirci, None; Alison Skalet, None; Yevgeniy Shildkrot, None; Stephen Deppen, None
  • Footnotes
    Support  NIH/NEI grant K08 EY 027464, Career Development Award from Research to Prevent Blindness, unrestricted grant from Research to Prevent Blindness to the Vanderbilt Department of Ophthalmology and Visual Sciences.
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 4027. doi:
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      Anthony B Daniels, Katherine S. Peters, Mark P Breazzano, William Choi, Jeanette Du, Nathan Law, Audra Miller, Max Aveis, Suleyman Ciftci, Amy C Schefler, Hakan Demirci, Alison Skalet, Yevgeniy Shildkrot, Stephen Deppen; Impact of different initial systemic staging imaging strategies on metastasis detection in uveal melanoma patients: The Melanoma of the Uvea Staging Imaging Consortium (MUSIC) Study. Invest. Ophthalmol. Vis. Sci. 2020;61(7):4027.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the necessary fields to image (chest, abdomen, and/or pelvis), and the most appropriate modality (X-ray, CT, MRI, ultrasound, or PET/CT) for initial staging to most effectively detect synchronous metastases of uveal melanoma (UM) present at the time of diagnosis of the ocular primary.

Methods : Multi-institutional retrospective study of patients diagnosed with UM at 5 large referral ocular oncology practices over a 5 year period. Initial imaging modality, field of imaging, radiographic findings, follow-up studies recommended and/or performed and their results, and final diagnoses were obtained for each patient from their medical record. Sensitivity and specificity were calculated, and factors impacting correct (or incorrect) radiographic diagnosis, were identified. The "number needed to screen" to identify a true metastasis within various fields or with various modalities was calculated.

Results : 1000 patients were included. 95% had abdominal imaging (5% had LFTs only), and 91% had chest imaging. The majority (62%) had imaging of the chest/abdomen/pelvis, including whole body imaging (12%). 26 patients (2.6%) had UM metastases. 13 patients had another biopsy-proven primary malignancy found. In 418 patients, a lesion was found in the abdomen. Out of these, 124 went on to have additional imaging, and of these, 25 were found to be metastatic disease. The sensitivity of radiologists’ calls of benign vs. malignant findings on CT of the abdomen was 35%, while the specificity was 85%. Sensitivity and specificity of MRI, US, and PET were better, but were used less frequently. 20 incidental pelvic lesions were found, but none were UM. Of the 373 patients in whom a chest lesion was found, 63 had additional imaging and 11 were confirmed to have metastasis in the chest. However, all-but-one of these patients also had metastases found in the liver. Chest imaging only identified 1 additional patient with metastases.

Conclusions : Liver imaging is the most beneficial for initial UM staging, and MRI or ultrasound may be preferable to CT. CT chest imaging identifies many incidental findings necessitating additional imaging studies, but identifies very few additional metastatic patients beyond liver imaging. Pelvic imaging was not shown to be beneficial in this study.

This is a 2020 ARVO Annual Meeting abstract.

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