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Sung Pyo Park; Intra- and interocular differences in parafoveal vascular density in diabetic patients without diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2020;61(7):4110.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the associations among optical coherence tomography angiography (OCTA)-measured vascular density (VD), intra- and interocular VD differences, and clinical factors in diabetic patients without diabetic retinopathy (DR).
We retrospectively reviewed 94 type 2 diabetic patients without DR who had undergone OCTA. VD and vessel skeleton density (SD) were measured in a 3-mm central zone in the total capillary plexus (TCP), superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris layers. Intraocular VD difference was determined between the superior and inferior zones, while interocular VD difference was determined between both eyes of the patient. Associations between OCTA parameters and clinical factors were evaluated.
VD and intra- and interocular VD differences were significantly associated with signal strength of the image which was related with age and lens opacity. In multivariate analysis, diabetes duration was negatively associated with SD in TCP and SCP layers, and positively associated with intraocular VD difference in SCP layer. Estimated glomerular filtration rate was negatively associated with intraocular SD difference in TCP layer, interocular VD and SD differences in TCP layer.
Intra- and interocular VD difference may be an easy and sensitive way to detect subtle early microvascular changes in diabetic patients.
This is a 2020 ARVO Annual Meeting abstract.
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