Abstract
Purpose :
To associate optical coherence tomography angiography (OCTA) features in retinal vein occlusions with visual outcomes after intravitreal antiangiogenic therapy (anti-VEGF).
Methods :
An analytical observational study was carried out in eyes with retinal vein occlusion treated with antiVEGF. Optical coherence tomography angiography (Optovue, Inc. RTVue) measures were analyzed including superficial capillary plexus, deep capillary plexus, foveal avascular zone within a 3x3-mm area and macular ischemia. Correlations were performed to evaluate the association between OCTA measurements and visual outcomes.
Results :
A total of 62 eyes (61 subjects), with a mean age of 70 ± 12,6 years were included. Median follow up time was 21,2 months (Q1 9,3 – Q3 34,1 months), 46,8% had central retinal vein occlusion (CRVO), 46,8% had branch retinal vein occlusion (BRVO) and 6,5% had hemi-central retinal vein occlusion (HRVO). Mean best-corrected visual acuity (BCVA) pre-treatment was 0,73 ± 0,48 LogMar and post-treatment was 0,65 ± 0,48 LogMar. This difference among BCVA was statistically significant in eyes with BRVO (p=0,01). Worse vision at baseline and a diagnosis of CRVO were associated to poor final visual acuity (p<0,05). Those who presented grade 4 macular ischemia based on parafoveal area and foveal avascular zone had a poor BCVA outcome. This association was statistically significant in BRVO eyes (p=0,026). Mean superficial capillary density was 37,6%± 6,3 and mean deep capillary density was 41,9%± 6,6 before treatment. Deep capillary density was higher in BRVO 42,2% (Q1 38,8% – Q3 45,9%), than CRVO 40,9% (Q1 37,3% – Q3 47,2%) (p=0,022), therefore associated with better visual outcome in BRVO
Conclusions :
Findings associated with visual outcomes were BCVA at baseline, type of occlusion, deep capillary density and the degree of macular ischemia in OCTA. Studies with a larger sample are required to assess the relevance of OCTA features with the final visual prognosis.
This is a 2020 ARVO Annual Meeting abstract.