June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
1a,25-dihydroxyvitamin D3 is Inversely Associated with Intraocular Pressure in Healthy Adults
Author Affiliations & Notes
  • Hana Abouzeid
    Clinical Eye Research Centre Memorial Adolphe de Rothschild, Geneva, Switzerland
    Institute for Research in Ophthalmology, Sion, Switzerland
  • Jean-Pierre Ghobril
    University of Lausanne, Institute for Social and Preventive Medicine, Switzerland
  • Daniel Fuster
    Geneva University Hospital, Switzerland
  • Idris Guessous
    Geneva University Hospital, Switzerland
  • Belen Ponte
    Geneva University Hospital, Switzerland
  • Yassine Bouatou
    Geneva University Hospital, Switzerland
  • Pierre-Yves Martin
    Geneva University Hospital, Switzerland
  • Menno Pruijm
    Geneva University Hospital, Switzerland
  • Daniel Ackermann
    Geneva University Hospital, Switzerland
  • Nasser Dhayat
    Geneva University Hospital, Switzerland
  • Bruno Vogt
    Geneva University Hospital, Switzerland
  • Gordana Sunaric-Megevand
    Clinical Eye Research Centre Memorial Adolphe de Rothschild, Geneva, Switzerland
  • Ananth Viswanathan
    Glaucoma, Moorfields Eye Hospital, London, United Kingdom
  • Murielle Bochud
    University of Lausanne, Institute for Social and Preventive Medicine, Switzerland
  • Footnotes
    Commercial Relationships   Hana Abouzeid, None; Jean-Pierre Ghobril, None; Daniel Fuster, None; Idris Guessous, None; Belen Ponte, None; Yassine Bouatou, None; Pierre-Yves Martin, None; Menno Pruijm, None; Daniel Ackermann, None; Nasser Dhayat, None; Bruno Vogt, None; Gordana Sunaric-Megevand, None; Ananth Viswanathan, None; Murielle Bochud, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 4767. doi:
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      Hana Abouzeid, Jean-Pierre Ghobril, Daniel Fuster, Idris Guessous, Belen Ponte, Yassine Bouatou, Pierre-Yves Martin, Menno Pruijm, Daniel Ackermann, Nasser Dhayat, Bruno Vogt, Gordana Sunaric-Megevand, Ananth Viswanathan, Murielle Bochud; 1a,25-dihydroxyvitamin D3 is Inversely Associated with Intraocular Pressure in Healthy Adults. Invest. Ophthalmol. Vis. Sci. 2020;61(7):4767.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose :
Glaucoma, an optic neuropathy causing vision loss, is the leading cause of irreversible blindness worldwide. Intraocular pressure (IOP) is a major modifiable risk factor for open-angle glaucoma incidence and progression, and its reduction is the only therapy proven to be efficient. We explored selected factors associated with IOP in the general adult population in Switzerland, with a focus on vitamin D.

Methods :
This is a cross-sectional analysis of the association between intraocular pressure and selected factors, including systemic vitamin D3 levels, using a multicentric population-based cohort in people of European-descent (SKIPOGH). A subset of SKIPOGH including 306 participants with available IOP and vitamin D measurements was included. IOP was measured by rebound tonometry. Plasma 25-hydroxyvitamin D3 was measured by a direct, competitive chemiluminescence immunoassay and 1,25-dihydroxyvitamin D3 by a competitive enzyme immunoassay.

Results : Mean IOP was 13.99 mmHg (SD 3.24). In multivariable mixed linear regression models, IOP was associated negatively with plasma 1,25-(OH)2-vitamin D3 (P value = 0.006). Every unit increase in log 1,25-(OH)2-vitamin D3 (nmol/L) was associated with 1.6 ± 0.5 mm Hg lower IOP, independently of age, sex, mean systemic blood pressure, body mass index, PTH, serum calcium and phosphate levels. By contrast, 25-(OH)-Vitamin D3 was not significantly associated with IOP, although the direction of the association was the same.

Conclusions : Intraocular pressure was associated negatively with plasma 1,25-(OH)2-vitamin D3, independently of systemic blood pressure, PTH and serum calcium, in the general adult population. The inverse association of IOP with the biologically active form of vitamin D3 is in line with animal experiments showing an IOP-lowering effect of vitamin D3. The putative protective effect of vitamin D3 on primary open-angle glaucoma should be tested in future randomized clinical trials.

This is a 2020 ARVO Annual Meeting abstract.

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