Abstract
Purpose :
To figure out features to improve detection of polypoidal lesions of polypoidal choroidal vasculopathy (PCV) on spectral domain optical coherence tomography angiography (SD-OCTA), through comparing the imaging and diagnostic features of SD-OCTA and swept-source OCTA (SS-OCTA).
Methods :
This is a retrospective and comparative study. PCV patients confirmed by indocyanine green angiography (ICGA) and received SD-OCTA and SS-OCTA examinations on the same day were included in the study. The OCTA images were firstly reviewed blinded to the findings of ICGA. Next, the morphological characteristics and detection rate of polypoidal lesions were compared and evaluated with ICGA as the golden standard. Finally, we compared the sensitivity and specificity of polypoidal lesions detection using the combination of features on angio-OCTA, cross-sectional OCTA, and en face structure OCT.
Results :
Twenty-two eyes of 20 patients were finally included. SS-OCTA had better detection rate for hyper-flow polypoidal lesions compared to SD-OCTA (p<0.01). Compared to angio-SS-OCTA, polypoidal lesions on SD-OCTA demonstrate three forms: hyper-flow signals (54%); undetectable signals (31%) and hypo-flow signals (15%). Besides, hypo-reflective signals on en face structure imaging of SD-OCTA (73%) are more evident than those on SS-OCTA (52%). Addition of this feature on en face structure imaging significantly improved the specificity of SD-OCTA (85%), with specificity unaffected.
Conclusions :
Focal hypo-reflective signals on en face structure imaging improved the detection of polypoidal lesions on SD-OCTA. The combination of the three imaging modalities (angio-OCTA, cross-sectional OCTA, and en face structure imaging) of SD-OCTA was recommended when using the SD-OCTA for PCV patients’ examinations.
This is a 2020 ARVO Annual Meeting abstract.