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Eileen Hwang, Jessica Kraker, Elizabeth Koller; Progression of partial posterior vitreous detachment over time. Invest. Ophthalmol. Vis. Sci. 2020;61(7):4821.
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Posterior vitreous detachment (PVD) progresses from stage 0 (no PVD), through stages 1 to 3 of partial PVD, and finally to stage 4 (complete PVD). Cross-sectional studies demonstrated that PVD stage increases with age and average vitreomacular adhesion area (VMAA) decreases. However, longitudinal studies capturing changes in individual eyes are lacking.
We retrospectively evaluated PVD stage and VMAA in asymptomatic eyes of retina clinic patients who underwent repeated optical coherence tomography (OCT) screening for high-risk medication use or isolated retinal disease in the fellow eye.
We evaluated 101 eyes of 101 patients (71 female, 30 male; average age 50 years). 76 eyes remained in the same stage over the entire follow up period (average length 4.7 years). 23 eyes progressed from a lower stage to a higher stage. The data were used to create a statistical model to predict time to convert from stages 0-3 to stage 4 PVD. At age 30, time to convert to stage 4 was predicted to be 26 years; at age 40, it was 16 years; at age 50, it was 9 years; and at age 60, it was 8 years. VMAA was assessed in repeated scans from 37 eyes with stage 1 partial PVD. The rate of change in VMAA was similar across all subjects. The average population level yearly decline in VMAA was 0.13 mm2.
Individuals vary in the age at which they progress to complete PVD, but the rate of VMAA change is similar between individuals.
This is a 2020 ARVO Annual Meeting abstract.
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