June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Periodic nano-textured micro-patterns on intraocular lens surface to regulate posterior capsular opacity
Author Affiliations & Notes
  • Choun-Ki Joo
    CK St. Mary's Eye Center, Korea (the Republic of)
  • Byoung-Chan Choi
    Advanced Technology Inc, Korea (the Republic of)
  • Jeewon Mok
    CK St. Mary's Eye Center R&D Center, Korea (the Republic of)
  • Hyun-Kwang Seok
    Korea Institute of Science and Technology, Korea (the Republic of)
  • Hojeong Jeon
    Korea Institute of Science and Technology, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Choun-Ki Joo, None; Byoung-Chan Choi, None; Jeewon Mok, None; Hyun-Kwang Seok, None; Hojeong Jeon, None
  • Footnotes
    Support  THIS WORK WAS SUPPORTED BY THE INDUSTRIAL STRATEGIC TECHNOLOGY DEVELOPMENT PROGRAM(PROJECT NO. 10060057) AND FUNDED BY THE MINISTRY OF TRADE, INDUSTRY & ENERGY(MOTIE, KOREA).
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 5033. doi:
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    • Get Citation

      Choun-Ki Joo, Byoung-Chan Choi, Jeewon Mok, Hyun-Kwang Seok, Hojeong Jeon; Periodic nano-textured micro-patterns on intraocular lens surface to regulate posterior capsular opacity. Invest. Ophthalmol. Vis. Sci. 2020;61(7):5033.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To identify the optimal patterning on the intraocular lens (IOL) by the synergistic effect of nano-textured micro-patterns to suppress undesirable cell migration and proliferation related to posterior capsular opacity (PCO) after cataract surgery

Methods : This experimental investigation used lens epithelial cells (LECs) and New Zealand white rabbits for in-vitro and in-vivo study, respectively. The periodic nano-textured micro-patterns were created with femtosecond laser ablation on IOL surface. The effect of both ridge (R) and groove width (G) of periodic nano-textured patterns (R5G3, R5G5, R5G10, R3G5, and R10G5) on adhesion, migration and proliferation of lens epithelial cell line (B-3) was evaluated. IOLs with the most effective pattern on its posterior surface (Group I, n=15) and without pattern (Group II, n=15) were implanted into rabbit eyes and retro-illuminated images of posterior capsule were taken at 2 months after cataract surgery. Both area and severity of PCO were measured by POCOman software in two groups.

Results : In-vitro study showed that all microgroove patterns reduced the migration rate of LECs by at least 73.05%, e.g., the average migration rate of LECs on the R5G10 pattern showed the slowest between all groups (28.35μm/day, which is 93.74% smaller than the migration rate of cells in the control group). With these results, in-vivo study was performed using IOL with the R5G10 pattern. After 2 months postoperatively, both PCO area and severity in group II (35.3% and 0.44) were lower than those in group I (72.3% [P=0.001] and 1.13 [P=0.009], respectively)

Conclusions : The nano-textured micro patterns on IOL may be effective to reduce the incidence of PCO after IOL implantation in cataract surgery.

This is a 2020 ARVO Annual Meeting abstract.

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