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Choun-Ki Joo, Byoung-Chan Choi, Jeewon Mok, Hyun-Kwang Seok, Hojeong Jeon; Periodic nano-textured micro-patterns on intraocular lens surface to regulate posterior capsular opacity. Invest. Ophthalmol. Vis. Sci. 2020;61(7):5033.
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© ARVO (1962-2015); The Authors (2016-present)
To identify the optimal patterning on the intraocular lens (IOL) by the synergistic effect of nano-textured micro-patterns to suppress undesirable cell migration and proliferation related to posterior capsular opacity (PCO) after cataract surgery
This experimental investigation used lens epithelial cells (LECs) and New Zealand white rabbits for in-vitro and in-vivo study, respectively. The periodic nano-textured micro-patterns were created with femtosecond laser ablation on IOL surface. The effect of both ridge (R) and groove width (G) of periodic nano-textured patterns (R5G3, R5G5, R5G10, R3G5, and R10G5) on adhesion, migration and proliferation of lens epithelial cell line (B-3) was evaluated. IOLs with the most effective pattern on its posterior surface (Group I, n=15) and without pattern (Group II, n=15) were implanted into rabbit eyes and retro-illuminated images of posterior capsule were taken at 2 months after cataract surgery. Both area and severity of PCO were measured by POCOman software in two groups.
In-vitro study showed that all microgroove patterns reduced the migration rate of LECs by at least 73.05%, e.g., the average migration rate of LECs on the R5G10 pattern showed the slowest between all groups (28.35μm/day, which is 93.74% smaller than the migration rate of cells in the control group). With these results, in-vivo study was performed using IOL with the R5G10 pattern. After 2 months postoperatively, both PCO area and severity in group II (35.3% and 0.44) were lower than those in group I (72.3% [P=0.001] and 1.13 [P=0.009], respectively)
The nano-textured micro patterns on IOL may be effective to reduce the incidence of PCO after IOL implantation in cataract surgery.
This is a 2020 ARVO Annual Meeting abstract.
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