June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Electrophysiological Assessment in Birdshot Chorioretinopathy: Use of a Portable Device in the Clinic
Author Affiliations & Notes
  • Anna Michelle Waldie
    Department of Ophthalmology, Sydney Eye Hospital, Sydney, New South Wales, Australia
    Faculty of Health and Medicine, The University of Sydney, Save Sight Institute, Sydney, New South Wales, Australia
  • Angharad E Hobby
    Department of Ophthalmology, St Thomas' Hospital, London, United Kingdom
    Division of Optometry and Visual Sciences, City, University of London, United Kingdom
  • Isabelle Chow
    Department of Ophthalmology, St Thomas' Hospital, London, United Kingdom
  • Elisa Eleanor Cornish
    Department of Ophthalmology, Sydney Eye Hospital, Sydney, New South Wales, Australia
    Faculty of Health and Medicine, The University of Sydney, Save Sight Institute, Sydney, New South Wales, Australia
  • Mathura Indusegaran
    Department of Ophthalmology, St Thomas' Hospital, London, United Kingdom
  • Alexandra Pekacka
    Department of Ophthalmology, St Thomas' Hospital, London, United Kingdom
  • Vuong Nguyen
    Faculty of Health and Medicine, The University of Sydney, Save Sight Institute, Sydney, New South Wales, Australia
  • Clare Fraser
    Department of Ophthalmology, Sydney Eye Hospital, Sydney, New South Wales, Australia
    Faculty of Health and Medicine, The University of Sydney, Save Sight Institute, Sydney, New South Wales, Australia
  • Alison M Binns
    Division of Optometry and Visual Sciences, City, University of London, United Kingdom
  • Miles R. Stanford
    Department of Ophthalmology, St Thomas' Hospital, London, United Kingdom
  • Christopher Hammond
    Department of Ophthalmology, St Thomas' Hospital, London, United Kingdom
  • Peter J McCluskey
    Department of Ophthalmology, Sydney Eye Hospital, Sydney, New South Wales, Australia
    Faculty of Health and Medicine, The University of Sydney, Save Sight Institute, Sydney, New South Wales, Australia
  • John R Grigg
    Department of Ophthalmology, Sydney Eye Hospital, Sydney, New South Wales, Australia
    Faculty of Health and Medicine, The University of Sydney, Save Sight Institute, Sydney, New South Wales, Australia
  • Omar Mahroo
    Department of Ophthalmology, St Thomas' Hospital, London, United Kingdom
    NIHR Biomedical Research Centre, Moorfields Eye Hospital and the UCL Insitute of Ophthalmology, United Kingdom
  • Footnotes
    Commercial Relationships   Anna Waldie, None; Angharad Hobby, None; Isabelle Chow, None; Elisa Cornish, None; Mathura Indusegaran, None; Alexandra Pekacka, None; Vuong Nguyen, None; Clare Fraser, None; Alison Binns, None; Miles Stanford, None; Christopher Hammond, None; Peter McCluskey, None; John Grigg, None; Omar Mahroo, None
  • Footnotes
    Support  Wellcome Trust (206619/Z/17/Z); Fight for Sight UK; Birdshot Uvietis Society; NIHR Biomedical Research Centre at Moorfields Eye Hospital and the UCL Institute of Ophthalmology
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 5045. doi:
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      Anna Michelle Waldie, Angharad E Hobby, Isabelle Chow, Elisa Eleanor Cornish, Mathura Indusegaran, Alexandra Pekacka, Vuong Nguyen, Clare Fraser, Alison M Binns, Miles R. Stanford, Christopher Hammond, Peter J McCluskey, John R Grigg, Omar Mahroo; Electrophysiological Assessment in Birdshot Chorioretinopathy: Use of a Portable Device in the Clinic. Invest. Ophthalmol. Vis. Sci. 2020;61(7):5045.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Electrophysiological monitoring in Birdshot Chorioretinopathy (BCR) provides an objective assessment of disease activity, and the light-adapted 30 Hz flicker electroretinogram (ERG) has been shown to be sensitive to retinal dysfunction. This study explored use of a hand-held, full-field electroretinographic device (RETeval, LKC Technologies Inc., Gaithersburg, MD, USA) in BCR patients.

Methods : We analysed light-adapted full-field flicker ERG responses from 32 BCR patients. Recordings were obtained with the portable device using skin electrodes and parameters were compared with those obtained using standard recording techniques with conventional equipment. A random number generator was used to select right or left eyes from each patient for statistical analysis.

Results : Mean ERG amplitudes were 17.9±10.7μV and 62.6±36.2μV for the portable and conventional recordings respectively. The amplitudes recorded by the two systems were significantly positively correlated (r=0.76, p<0.0001, n=32; Pearson correlation coefficient). The mean peak time from the RETeval™ flicker ERG was 31.4±4.4ms, which was slightly shorter than the mean peak time from conventional ERGs, which was 32.9±7.1ms. The peak times were significantly positively correlated (r = 0.53, p = 0.002, n=32; Pearson correlation coefficient).

Conclusions : ERG results obtained by portable device correlated significantly with conventional ERG recordings. Our results suggest that portable recordings could potentially be used in the office setting to provide a rapid assessment of generalised cone system function in these patients, and might be applicable to other retinal diseases. Replication of these findings, and formal repeatability studies will be helpful.

This is a 2020 ARVO Annual Meeting abstract.

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