June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Characteristics and Findings of Patient Population Sent for Hydroxychloroquine (HCQ) Maculopathy Screening
Author Affiliations & Notes
  • Gaurav Kiri
    Ophthalmology, University of South Florida, Tampa, Florida, United States
  • Swetangi Bhaleeya
    Ophthalmology, University of South Florida, Tampa, Florida, United States
  • Peter Pavan
    Ophthalmology, University of South Florida, Tampa, Florida, United States
  • Radouil T Tzekov
    Ophthalmology, University of South Florida, Tampa, Florida, United States
  • Footnotes
    Commercial Relationships   Gaurav Kiri, None; Swetangi Bhaleeya, None; Peter Pavan, None; Radouil Tzekov, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 5046. doi:
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      Gaurav Kiri, Swetangi Bhaleeya, Peter Pavan, Radouil T Tzekov; Characteristics and Findings of Patient Population Sent for Hydroxychloroquine (HCQ) Maculopathy Screening. Invest. Ophthalmol. Vis. Sci. 2020;61(7):5046.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The purpose of this study was to examine the clinical and vision function characteristics of patients sent for HCQ maculopathy screening in a tertiary university hospital.

Methods : This was a retrospective review of patients’ records for patients that underwent HCQ maculopathy screening between December 2014 and October 2019 at USF Eye Institute, Tampa, FL. External referrals were excluded from this analysis. Only patients who underwent multifocal electroretinography (mfERG) were included. Recording of mfERG was performed binocularly on Espion mfERG system (Diagnosys LLC: Lowell, MA) with DTL electrodes using 61 hexagons stimulus, according to ISCEV mfERG standards. Ring ratios (R1/R2, R5/R3 and R5/R4) were used to screen for incipient maculopathy. The ring ratios normal limits were based on Browning & Lee (Clin Ophthalmol. 2014; 8: 1467–1473).

Results : The retrospective review identified the records of 40 patients (4 males, 36 females), aged 54.7 +/- 14.1 years. On initial mfERG evaluation, 8 patients (20%) showed more than one mfERG ring ratio which was abnormal in at least one eye. In 7 patients (17.5%), R1/R2 ring ratio was abnormal with 1 patient showing abnormality in both eyes. In 10 patients (25.0%), R5/R3 ring ratio was abnormal with 2 patients showing abnormality in both eyes. In 11 patients (27.5%), R5/R4 ring ratio was abnormal with 4 patients showing abnormality in both eyes. The average best corrected visual acuity was 0.095 logMAR for right eye and 0.198 logMAR for left eye (~20/25, ~20/32 respectively). For the 7 patients who had abnormal R1/R2 ring ratios in at least one eye, the average visual acuity was 0.103 logMAR for right eye and 0.078 logMAR for left eye (~20/25, ~20/24 respectively) but there appeared to be no statistically significant difference in visual acuity with the rest of the patients (p>0.05, Mann-Whitney test). For 11 patients, at least one mfERG follow-up testing was available at an average period of 1.2 +- 0.6 years. For this group, R1/R2 ring ratios increased in 8 eyes and decreased in 14 eyes, although none of the eyes in that the ratio increased were considered to have maculopathy.

Conclusions : This analysis could lead to better understanding of the spectrum of visual function in patients screened for HCQ Maculopathy

This is a 2020 ARVO Annual Meeting abstract.

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