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Monica Del-Rio-Vellosillo, Elena Rubio-Velazquez, Raquel Agustina Góngora-Rodríguez, Dolores Párraga-Muñoz, Vicente Zanon-Moreno, Maria D. Pinazo-Duran, Juan Jose Zafra-Perez, Jose Javier Garcia Medina; Retinal thickness and vascular parameters estimated by OCT and OCT angiography in autism spectrum disorder. Invest. Ophthalmol. Vis. Sci. 2020;61(7):5106.
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© ARVO (1962-2015); The Authors (2016-present)
The aim of this study was to compare retinal thicknesses and vascular parameters between autism spectrum disorder (ASD) and neurotypical (NT) individuals.
14 eyes of 14 high-functioning ASD subjects and 14 eyes of 14 age- and sex-matched NT participants underwent 4 scans with the device Cirrus HD-OCT 5000 (Zeiss): macular cube, optic nerve cube, macular and optic nerve head (ONH) OCT angiography (OCT-A). Concerning OCT, thickness of full retina in 9 sectors of macular ETDRS pattern and peripapillary retinal nerve fiber layer (pRNFL) in 4 quadrants and 12 clock-hour sectors were considered. Vessel density and capillary perfusion density in 9 sectors were measured using macular OCT-A. ONH OCT-A estimated perfusion density and flux index in 4 peripapillary quadrants. Comparions between groups of these parameters were performed using U Mann-Whitney test.
ASD subjects showed higher ONH perfusion density and lower ONH flux index at the inferior quadrant when compared with NT individuals (p<0.05). Plus, a trend towards higher macular thickness, higher pRNFL thickness at inferior clock-hour sectors and higher macular vessel density and perfusion was observed in ASD.
Retinas of ASD subjects may present some structural and vascular differences when compared with retinas of NT individuals.
This is a 2020 ARVO Annual Meeting abstract.
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