June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Retinal thickness and vascular parameters estimated by OCT and OCT angiography in autism spectrum disorder
Author Affiliations & Notes
  • Monica Del-Rio-Vellosillo
    University Hospital La Arrixaca, Murcia, Spain
  • Elena Rubio-Velazquez
    General University Hospital Morales Meseguer, Murcia, Spain
  • Raquel Agustina Góngora-Rodríguez
    General University Hospital Morales Meseguer, Murcia, Spain
  • Dolores Párraga-Muñoz
    General University Hospital Morales Meseguer, Murcia, Spain
  • Vicente Zanon-Moreno
    Valencian International University - VIU, Valencia, Spain
  • Maria D. Pinazo-Duran
    Ophthalmic Research Unit "Santiago Grisolía"/FISABIO, Valencia, Spain
  • Juan Jose Zafra-Perez
    General University Hospital Morales Meseguer, Murcia, Spain
  • Jose Javier Garcia Medina
    General University Hospital Morales Meseguer, Murcia, Spain
    Ophthalmology, University of Murcia, Murcia, Spain
  • Footnotes
    Commercial Relationships   Monica Del-Rio-Vellosillo, None; Elena Rubio-Velazquez, None; Raquel Agustina Góngora-Rodríguez, None; Dolores Párraga-Muñoz, None; Vicente Zanon-Moreno, None; Maria Pinazo-Duran, None; Juan Jose Zafra-Perez, None; Jose Javier Garcia Medina, None
  • Footnotes
    Support  Red Temática de Investigación cooperativa OFTARED RD16/0008/0022, Valencia, Spain
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 5106. doi:
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      Monica Del-Rio-Vellosillo, Elena Rubio-Velazquez, Raquel Agustina Góngora-Rodríguez, Dolores Párraga-Muñoz, Vicente Zanon-Moreno, Maria D. Pinazo-Duran, Juan Jose Zafra-Perez, Jose Javier Garcia Medina; Retinal thickness and vascular parameters estimated by OCT and OCT angiography in autism spectrum disorder. Invest. Ophthalmol. Vis. Sci. 2020;61(7):5106.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The aim of this study was to compare retinal thicknesses and vascular parameters between autism spectrum disorder (ASD) and neurotypical (NT) individuals.

Methods : 14 eyes of 14 high-functioning ASD subjects and 14 eyes of 14 age- and sex-matched NT participants underwent 4 scans with the device Cirrus HD-OCT 5000 (Zeiss): macular cube, optic nerve cube, macular and optic nerve head (ONH) OCT angiography (OCT-A). Concerning OCT, thickness of full retina in 9 sectors of macular ETDRS pattern and peripapillary retinal nerve fiber layer (pRNFL) in 4 quadrants and 12 clock-hour sectors were considered. Vessel density and capillary perfusion density in 9 sectors were measured using macular OCT-A. ONH OCT-A estimated perfusion density and flux index in 4 peripapillary quadrants. Comparions between groups of these parameters were performed using U Mann-Whitney test.

Results : ASD subjects showed higher ONH perfusion density and lower ONH flux index at the inferior quadrant when compared with NT individuals (p<0.05). Plus, a trend towards higher macular thickness, higher pRNFL thickness at inferior clock-hour sectors and higher macular vessel density and perfusion was observed in ASD.

Conclusions : Retinas of ASD subjects may present some structural and vascular differences when compared with retinas of NT individuals.

This is a 2020 ARVO Annual Meeting abstract.

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