June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
ACCOMMODATIVE LENS EQUATOR POSITIONING AND CILIARY MUSCLE (CM) AND CILIARY PROCESS’ (CP) AREA IN THE AGING EYE
Author Affiliations & Notes
  • Mary Ann Croft
    Ophthalmology, Univ of Wisconsin-Madison, Madison, Wisconsin, United States
  • Jared McDonald
    Ophthalmology, Univ of Wisconsin-Madison, Madison, Wisconsin, United States
  • T Michael Nork
    Ophthalmology, Univ of Wisconsin-Madison, Madison, Wisconsin, United States
  • Gregg A Heatley
    Ophthalmology, Univ of Wisconsin-Madison, Madison, Wisconsin, United States
  • Paul L Kaufman
    Ophthalmology, Univ of Wisconsin-Madison, Madison, Wisconsin, United States
    Wisconsin National Primate Research Center, UW - Madison, Madison, Wisconsin, United States
  • Footnotes
    Commercial Relationships   Mary Ann Croft, Bridge Labs (R), Z Lens (F); Jared McDonald, None; T Michael Nork, None; Gregg Heatley, None; Paul Kaufman, Vista Ocular (F), Z-Lens LLC (F)
  • Footnotes
    Support  RO1 EY10213, R21 EY018370 & EY025359 to PLK, Core Grant for Vision Research Grant # P30 EY016665), RPB, NIH Grant # 5P51 RR 000167 to WNPRC, OPREF.
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 5137. doi:
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    • Get Citation

      Mary Ann Croft, Jared McDonald, T Michael Nork, Gregg A Heatley, Paul L Kaufman; ACCOMMODATIVE LENS EQUATOR POSITIONING AND CILIARY MUSCLE (CM) AND CILIARY PROCESS’ (CP) AREA IN THE AGING EYE. Invest. Ophthalmol. Vis. Sci. 2020;61(7):5137.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The accommodative forward movement of the lens equator is significantly related to accommodative amplitude [Croft, Kaufman; IOVS 2013]. Our goal was to determine if the lens equator position in the resting or accommodated eye is dependent upon resting CM area and/or the CP area in human subjects of varying ages.

Methods : The eyes of 12 human subjects (aged 19-65 yrs) were studied. Ultrasound biomicroscopy (UBM; 50 MHz, 35 MHz) images were collected in the region of the lens/capsule and ciliary body following 1 drop of 5 % homatropine to induce disaccommodation and following 2 drops of 4% pilocarpine to induce maximum accommodative responses.

Results : CM Area: The homatropinized (HOM) or pilocarpinized (PILO) A/P (anterior/posterior) lens equator position was unrelated to the amount of resting CM area. However, the centripetal (medial/lateral; ML) position of the resting (HOM) lens equator with respect to the scleral spur was related to the amount of resting (HOM) CM area (slope= - 0.28 ± 0.11 mm/mm2 ; p=0.039); the larger the CM area, the shorter the ML distance between the lens equator position and the scleral spur.
CP Area: In the pilocarpinized eye, the A/P lens equator position with respect to the scleral spur tended to be related to the amount of resting CP area (slope = -0.61 ± 0.26 mm/ mm2; p=0.064); the larger the resting CP area, the less forward (more unaccommodated) was the AP lens equator position. Further, there was a significant relationship between the accommodative A/P forward movement of the lens equator position and the amount of resting CP area (slope= - 0.86 ± 0.15 mm/mm2 ; p<0.002); with increased resting CP area, the less was the accommodative forward movement of the A/P lens equator position.
In addition, there was a significant relationship between ML lens equator position in the PILO eye and the amount of resting CP area (slope= - 0.72 ± 0.28 mm/mm2; p=0.048); the smaller the resting CP area, the greater the ML distance between the scleral spur and the lens equator.

Conclusions : At rest and during accommodation the lens equator position is dependent upon resting CP area (which increases with age). Maintaining the size/area of the CPs as seen in the young eye may be important to accommodative amplitude as we age - at least in part. Results of the CM and CP coordinates that define their shape and how they relate to accommodation will be discussed.

This is a 2020 ARVO Annual Meeting abstract.

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