June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
A 12-Year Analysis of Incidence, Microbiological Profiles, and In Vitro Antimicrobial Susceptibility of Infectious Keratitis: The Nottingham Eye Study
Author Affiliations & Notes
  • Darren S J Ting
    Academic Ophthalmology, University of Nottingham, Kegworth, United Kingdom
    Ophthalmology, Queen's Medical Centre, Nottingham, United Kingdom
  • Jessica Cairns
    School of Medicine, University of Nottingham, Nottingham, United Kingdom
  • Charlotte S Ho
    School of Medicine, University of Nottingham, Nottingham, United Kingdom
  • Mouhamed Al-aqaba
    Academic Ophthalmology, University of Nottingham, Kegworth, United Kingdom
  • Ahmad F Elsahn
    Academic Ophthalmology, University of Nottingham, Kegworth, United Kingdom
    Ophthalmology, Queen's Medical Centre, Nottingham, United Kingdom
  • Tim Boswell
    Microbiology, Queen's Medical Centre, United Kingdom
  • Dalia G Said
    Academic Ophthalmology, University of Nottingham, Kegworth, United Kingdom
    Ophthalmology, Queen's Medical Centre, Nottingham, United Kingdom
  • Harminder Dua
    Academic Ophthalmology, University of Nottingham, Kegworth, United Kingdom
    Ophthalmology, Queen's Medical Centre, Nottingham, United Kingdom
  • Footnotes
    Commercial Relationships   Darren S J Ting, None; Jessica Cairns, None; Charlotte Ho, None; Mouhamed Al-aqaba, None; Ahmad Elsahn, None; Tim Boswell, None; Dalia Said, None; Harminder Dua, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 5220. doi:
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      Darren S J Ting, Jessica Cairns, Charlotte S Ho, Mouhamed Al-aqaba, Ahmad F Elsahn, Tim Boswell, Dalia G Said, Harminder Dua; A 12-Year Analysis of Incidence, Microbiological Profiles, and In Vitro Antimicrobial Susceptibility of Infectious Keratitis: The Nottingham Eye Study. Invest. Ophthalmol. Vis. Sci. 2020;61(7):5220.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the incidence, causative microorganisms, and in vitro antimicrobial susceptibility and resistance profiles of infectious keratitis (IK) in Nottingham, UK.

Methods : This was a retrospective study of all patients who were diagnosed with IK and underwent corneal scraping between September 2007 and November 2019 (a 12-year period) at a UK tertiary referral centre. Relevant data, including demographic factors, microbiological profiles, in vitro antibiotic susceptibility and resistance of IK, were analysed.

Results : The estimated incidence of IK in this region was 15.6 per 100,000 people, with a relatively stable trend. Of the 1405 corneal scrapes, 502 (35.7%) were culture-positive and 572 causative microorganisms were identified. Sixty (4.3%) cases were of polymicrobial origin (caused by 2 or more different microorganisms). Pseudomonas aeruginosa (135, 23.6%) was the most commonly isolated organism, followed by Staphylococcus aureus (91, 15.9%) and Streptococci spp. (77, 13.5%). There was a significant increase in Moraxella spp. (p<0.001) and significant decrease in Klebsiella spp. (p=0.004) over time. The in vitro susceptibility of Gram-positive and Gram-negative bacteria to cefuroxime, fluoroquinolone, and aminoglycosides were 100.0% and 81.3%, 90-100% and 97.8-100.0%, and 95.2% and 98.3-98.9%, respectively. An increase in resistance against penicillin was observed in both Gram-positive (3.5% to 12.7%; p=0.005) and Gram-negative bacteria (from 52.6% to 65.4%; p=0.22).

Conclusions : IK represents a relatively common and persistent burden in the UK and the reported incidence is likely to be underestimated. P. aeruginosa was the most common culprit for IK in our region. Current broad-spectrum antimicrobial treatment provides a good treatment coverage for IK, albeit challenged by some level of antimicrobial resistance and polymicrobial infection.

This is a 2020 ARVO Annual Meeting abstract.

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