June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Compare Wide-field Swept-Source Optical Coherence Tomography Angiography with Ultra-wide Field Color Fundus Photo and Fluorescein Angiography for Detecting Diabetic Retinopathy Lesions
Author Affiliations & Notes
  • Ying Cui
    Ophthalmology, Mass eye and ear, Harvard Medical School, Brookline, Massachusetts, United States
    Ophthalmology, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China
  • Ying Zhu
    Ophthalmology, Mass eye and ear, Harvard Medical School, Brookline, Massachusetts, United States
    Ophthalmology, Xiangya Hospital, Central South University, Changsha, Hunan, China
  • Jay Wang
    Ophthalmology, Mass eye and ear, Harvard Medical School, Brookline, Massachusetts, United States
  • Yifan Lu
    Ophthalmology, Mass eye and ear, Harvard Medical School, Brookline, Massachusetts, United States
  • Rebecca Zeng
    Boston University School of Medicine, Boston, Massachusetts, United States
  • Raviv Katz
    Ophthalmology, Mass eye and ear, Harvard Medical School, Brookline, Massachusetts, United States
  • David M Wu
    Ophthalmology/Vitreoretinal Surgery, Wilmer Eye Institute,John Hopkins University, Maryland, United States
  • Demetrios G Vavvas
    Ophthalmology, Mass eye and ear, Harvard Medical School, Brookline, Massachusetts, United States
  • Deeba Husain
    Ophthalmology, Mass eye and ear, Harvard Medical School, Brookline, Massachusetts, United States
  • Joan W Miller
    Ophthalmology, Mass eye and ear, Harvard Medical School, Brookline, Massachusetts, United States
  • Leo A Kim
    Ophthalmology, Mass eye and ear, Harvard Medical School, Brookline, Massachusetts, United States
  • John B Miller
    Ophthalmology, Mass eye and ear, Harvard Medical School, Brookline, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Ying Cui, None; Ying Zhu, None; Jay Wang, None; Yifan Lu, None; Rebecca Zeng, None; Raviv Katz, None; David Wu, None; Demetrios Vavvas, None; Deeba Husain, None; Joan Miller, KalVista Pharmaceuticals (C), Lowy Medical Research Institute (F), ONL Therapeutics (C), ONL Therapeutics (P), ONL Therapeutics (I), Sunovion (C), Valeant Pharmaceuticals/Mass.Eye and Ear (P), Valeant Pharmaceuticals/Mass.Eye and Ear (R); Leo Kim, None; John Miller, Carl Zeiss Meditec.Inc. (C), Heidelberg Engineering Inc. (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 5294. doi:
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      Ying Cui, Ying Zhu, Jay Wang, Yifan Lu, Rebecca Zeng, Raviv Katz, David M Wu, Demetrios G Vavvas, Deeba Husain, Joan W Miller, Leo A Kim, John B Miller; Compare Wide-field Swept-Source Optical Coherence Tomography Angiography with Ultra-wide Field Color Fundus Photo and Fluorescein Angiography for Detecting Diabetic Retinopathy Lesions. Invest. Ophthalmol. Vis. Sci. 2020;61(7):5294.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare wide-field swept-source optical coherence tomography angiography (WF SS-OCTA) with ultra-wide field color fundus photo (UWF CFP) and fluorescein angiography (FA) for detecting diabetic retinopathy lesions

Methods : We conducted a prospective, observational study at Mass Eye and Ear from December 2018 to October 2019. Proliferative diabetic retinopathy (PDR), non-proliferative diabetic retinopathy (NPDR) and diabetic patients with no DR were included. All patients were imaged with a WF SS-OCTA with Montage 15mm×9mm. UWF CFP and FA were taken by a 200 degree, single capture retinal imaging system. Images were independently evaluated by two graders for the presence or absence of DR lesions including microaneurysms, intraretinal microvascular abnormalities (IRMA), neovascularization elsewhere (NVE) and neovascularization of the optic disc (NVD), nonperfusion areas (NPAs). All statistical analyses were performed using SPSS 25.0.

Results : One hundred and fifty-two eyes in 101 participants were included in the study. The average age of the participants was 54.26±13.40 years, and diabetes duration was 17.81±10.93 years. Eighty eyes had diabetic macular edema and 81 eyes were treatment naïve at the time of imaging. WF SS-OCTA had better performance in detecting IRMA (69.1% VS. 44.1%, P=0.000) and NVE/NVD (39.5% VS. 30.3%, P=0.007) except MA ( 80.3% VS. 88.2%, P=0.004), when compared with UWF CFP. The detection rate of MA, IRMA, NVE/NVD and NPAs in WF SS-OCTA are comparable with UWF FA images in 48 eyes of 34 participants (P>0.05). Furthermore, When we compare WF SS-OCTA plus UWF CFP and UWF FA, the detection rate of MA, IRMA and NVE/NVD are almost the same (P=1.000). Perfect agreement (κ=0.874) between WF SS-OCTA (Montage 15mm×9mm) and UWF FA was found to grade PDR and NPDR.

Conclusions : WF SS-OCTA (Montage 15mm×9mm) was useful in detecting DR lesions compared with UWF CFP and FA. It will be a better choice to follow-up severe NPDR and PDR patients.

This is a 2020 ARVO Annual Meeting abstract.

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