June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Usefulness of photopic and scotopic microperimetry in the early diagnosis of macular toxicity secondary to hydroxychloroquine use
Author Affiliations & Notes
  • Oswaldo Esteban Duran Carrasco
    OPHTHALMOLOGY, HOSPITAL DE LA CANDELARIA, Santa Cruz De Tenerife, STA CRUZ DE TFE, Spain
  • Consuelo Fernández-Núñez
    OPHTHALMOLOGY, HOSPITAL DE LA CANDELARIA, Santa Cruz De Tenerife, STA CRUZ DE TFE, Spain
  • María Alberto-Pestano
    OPHTHALMOLOGY, HOSPITAL DE LA CANDELARIA, Santa Cruz De Tenerife, STA CRUZ DE TFE, Spain
  • Nicolás Pérez-Llombet-Quintana
    OPHTHALMOLOGY, HOSPITAL DE LA CANDELARIA, Santa Cruz De Tenerife, STA CRUZ DE TFE, Spain
  • Marta Alonso-Plasencia
    OPHTHALMOLOGY, HOSPITAL DE LA CANDELARIA, Santa Cruz De Tenerife, STA CRUZ DE TFE, Spain
  • Ruyman Rodríguez-Gil
    OPHTHALMOLOGY, HOSPITAL DE LA CANDELARIA, Santa Cruz De Tenerife, STA CRUZ DE TFE, Spain
  • Rodrigo Abreu-González
    OPHTHALMOLOGY, HOSPITAL DE LA CANDELARIA, Santa Cruz De Tenerife, STA CRUZ DE TFE, Spain
  • Footnotes
    Commercial Relationships   Oswaldo Esteban Duran Carrasco, None; Consuelo Fernández-Núñez, None; María Alberto-Pestano, None; Nicolás Pérez-Llombet-Quintana, None; Marta Alonso-Plasencia, None; Ruyman Rodríguez-Gil, None; Rodrigo Abreu-González, None
  • Footnotes
    Support  NONE
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 5320. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Oswaldo Esteban Duran Carrasco, Consuelo Fernández-Núñez, María Alberto-Pestano, Nicolás Pérez-Llombet-Quintana, Marta Alonso-Plasencia, Ruyman Rodríguez-Gil, Rodrigo Abreu-González; Usefulness of photopic and scotopic microperimetry in the early diagnosis of macular toxicity secondary to hydroxychloroquine use. Invest. Ophthalmol. Vis. Sci. 2020;61(7):5320.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : The exact mechanism of how hydroxychloroquine produces macular toxicity is still uncertain and unpredictable. That is why we propose microperimetry as a method for early detection retinal sensitivity decreased, even in patients with normal funduscopic images and without structural OCT alterations.

Methods : Microperimetry was performed using the Nidek MP3s equipment (Hiroshi, Japan) using a 13-point fovea-centered pattern, in photopic and scotopic mode in 25 eyes of 13 patients undergoing treatment with hydroxychloroquine that did not present fundoscopic alteration or structural OCT changes compatible with maculopathy. The same protocol was applied in a group of 41 eyes of 22 healthy volunteers, all of them with a corrected visual acuity of 1.0 on a decimal scale (0.00 Log Mar) and a spherical equivalent less than +/- 5.0 D. Subsequently, the data was processed using descriptive analytics, T- Student and mean difference.

Results : The chloroquine use time mean was 6.04 years (range 1-16 years), the average VA of this group is 0.04 (Log MAR), the photopic mean retinal sensitivity (MRS) in the study group was 26.75 dB (SE = 0. 14 ) while in the healthy group 29.49 dB (SE = 0.32 ) and in scotopic mode the mean in the study group was 14.5 dB (SE = 0.32), and 13.38 dB (SE = 0.28 ) in the control group, presenting a significant statistical difference (p <0.05) in both photopic and scotopic modes.
The central retinal sensitivity (CRS) also showed a significant difference in both modes (p <0.05), the average being for the study group 26.52 dB (SE = 0.8) and 29.22 dB (SE = 0.38) in the control group in photopic mode; and on the scotopic examination 10.86 dB (SE = 0.36) and 12.28 dB (SE = 0.40) for study and control group respectively.

Conclusions : The mean retinal sensitivity in patients who use hydroxychloroquine is significantly lower than MRS in persons who do not use it; in both photopic and scotopic microperimetry mode. This is why we consider that microperimetry test could be a good alternative to screen and to follow hydroxychloroquine related maculopathy.

This is a 2020 ARVO Annual Meeting abstract.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×