June 2020
Volume 61, Issue 7
ARVO Annual Meeting Abstract  |   June 2020
Structural and angiographic findings studied with optical coherence tomography (OCT) in a pediatric Mexican population with metabolic syndrome.
Author Affiliations & Notes
  • Andrea K. Montero-De-Anda
    Universidad de Guadalajara, San Juan de los Lagos, Jalisco, Mexico
  • Tatiana Velasquez-Tovar
    Universidad del Valle de México, Mexico
  • Mariana Ingolotti
    Hospital Universitario Austral, Argentina
  • Humberto Ruiz-Garcia
    Clínica Santa Lucía, Mexico
  • Footnotes
    Commercial Relationships   Andrea K. Montero-De-Anda, None; Tatiana Velasquez-Tovar, None; Mariana Ingolotti, None; Humberto Ruiz-Garcia, Alcon (R), Allergan (R), Carl Zeiss Meditech (R)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 5328. doi:
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      Andrea K. Montero-De-Anda, Tatiana Velasquez-Tovar, Mariana Ingolotti, Humberto Ruiz-Garcia; Structural and angiographic findings studied with optical coherence tomography (OCT) in a pediatric Mexican population with metabolic syndrome.. Invest. Ophthalmol. Vis. Sci. 2020;61(7):5328.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To analyze and compare structural and angiographic parameters obtained with OCT between a group of pediatric patients with metabolic syndrome and healthy controls.

Methods : This is a cohort study in which 40 eyes of 20 consecutive patients were classified into two groups: The eyes of 10 pediatric patients with metabolic syndrome (Group 1) and the eyes of 10 healthy controls (Group 2). Patients between the ages of 4-14 underwent complete ophthalmic exam and were imaged with macular and optic nerve spectral-domain optical coherence tomography (SD-OCT) and OCT angiography (OCT-A) (Carl Zeiss Meditec, Dublin, CA). Retinal nerve fiber layer thickness (RNFL), foveal avascular zone diameter (FAZ), vessel density and perfusion values, central retinal thickness and choroidal thickness values were evaluated. Manual FAZ measurements were performed by two different operators using OCT-A measuring tool.

Results : The age of the patients ranged from 4 to 14 years (mean age, 9 ± 4.02 years) and their SD-OCT findings document that there is not statistical difference in the area, perimeter or circularity of the FAZ between the two groups (P= 0.49).

A relative decrease in vessel density ( 17.6 vs 18.2mm/mm2) and perfusion percentage (43% vs 44.4%) that approached statistical significance was found in the study group in the 3x3 mm central macular cube. (p=0.008) and (p=0.043).

Obese patients had a thicker average RNFL (101.6u vs 91.85u), (P= 0.0022), but a relative decrease in the RNFL thickness was found in the nasal y temporal quadrants.

Conclusions : Our study found a trend of differences in structural and vascular parameters between obese children and healthy controls. Further research is necessary to demonstrate the developmental and functional significance of a thicker average RNFL in the group with the metabolic syndrome as well as the significance of the early vascular changes measured by OCT-A. Obesity has been linked to a chronic inflamatory state which made lead to this early findings.

This is a 2020 ARVO Annual Meeting abstract.


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