June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Repeatability, Interocular Symmetry, and Correlation with Age of Peripapillary Optical Coherence Tomography Angiography Parameters in Healthy Eyes
Author Affiliations & Notes
  • Cason B Robbins
    Duke University School of Medicine, Durham, North Carolina, United States
  • Dilraj Grewal
    Duke Eye Center, Durham, North Carolina, United States
  • Atalie C Thompson
    Duke Eye Center, Durham, North Carolina, United States
  • Stephen Yoon
    Duke Eye Center, Durham, North Carolina, United States
  • Brenda Plassman
    Neurology, Duke University Medical Center, North Carolina, United States
  • Sharon Fekrat
    Duke Eye Center, Durham, North Carolina, United States
  • Footnotes
    Commercial Relationships   Cason Robbins, None; Dilraj Grewal, None; Atalie Thompson, None; Stephen Yoon, None; Brenda Plassman, None; Sharon Fekrat, Alcon (P)
  • Footnotes
    Support  Alzheimer's Drug Discovery Foundation Grant, NIH Grant P30EY005722; Research to Prevent Blindness Grant, Karen L. Wrenn Alzheimer's Travel Grant
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 5343. doi:
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      Cason B Robbins, Dilraj Grewal, Atalie C Thompson, Stephen Yoon, Brenda Plassman, Sharon Fekrat; Repeatability, Interocular Symmetry, and Correlation with Age of Peripapillary Optical Coherence Tomography Angiography Parameters in Healthy Eyes. Invest. Ophthalmol. Vis. Sci. 2020;61(7):5343.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Peripapillary optical coherence tomography angiography (OCTA) is used to measure blood flow around the optic nerve head (ONH). This prospective, cross-sectional study assesses the intrasession repeatability of vessel density (VD = ratio of vessel-containing area to the total scan area) and normalized flux index (NFI = unitless ratio describing particle flow in a cross-section of vasculature per unit time) measurements on OCTA. We also report interocular differences and correlate these parameters with age.

Methods : Adults ≥ 50 years old without diabetes, uncontrolled hypertension, glaucoma, retinal disease, or prior retinal surgery underwent spectral-domain OCTA imaging using the Zeiss Cirrus HD-5000 AngioPlex (Version 11.0). Two to four 4.5x4.5mm ONH-centered OCTA images were acquired during a single visit. Images with motion artifact, segmentation artifact, or signal loss were not analyzed. Repeatability of VD and NFI was assessed by intraclass correlation, mean interocular differences were compared using two-tailed t test, and correlation with age was assessed using generalized estimating equations.

Results : A total of 154 images were acquired from 75 eyes of 47 patients. Eighty-seven right eye images and 67 left eye images were acquired. For VD, intraclass correlation results and limits of agreement (LoA) were calculated for quadrants and the whole peripapillary area: superior (0.8440, -0.038 to 0.035), nasal (0.7160, -0.049 to 0.045), inferior (0.9070, -0.034 to 0.037), temporal (0.7371, -0.054 to 0.051), average (0.9218, -0.020 to 0.018) (all p < 0.001). For NFI, intraclass correlation and LoA values are: superior (0.7195, -0.058 to 0.052), nasal (0.7751, -0.055 to 0.055), inferior (0.8976, -0.031 to 0.033), temporal (0.6167, -0.072 to 0.075), average (0.8684, -0.031 to 0.033) (all p < 0.001). There was no significant interocular difference in VD or NFI. VD and NFI negatively correlated with age in all quadrants (average VD ß-coefficient -0.0017336, p < 0.001; average NFI ß-coefficient -0.0027249, p < 0.001).

Conclusions : Excellent repeatability was observed for average VD; temporal and nasal VD had moderate repeatability. Average NFI had good repeatability; superior and temporal NFI had moderate repeatability. Interocular differences in VD and NFI are minimal. Correlation analysis shows these parameters decrease with age in healthy eyes.

This is a 2020 ARVO Annual Meeting abstract.

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