June 2020
Volume 61, Issue 7
ARVO Annual Meeting Abstract  |   June 2020
Effect of age, race, sex and state of residence on ocular inflammatory and infectious diseases in the United States
Author Affiliations & Notes
  • Krati Chauhan
    Internal Medicine, Southern Illinois University School of Medicine, Springfield, Illinois, United States
  • James Rosenbaum
    ophthalmology, Oregon Health & Science University-School of Medicine, Portland, Oregon, United States
    Ophthalmology, Legacy Devers Eye Institute,, Portland, Oregon, United States
  • Footnotes
    Commercial Relationships   Krati Chauhan, None; James Rosenbaum, Abbvie (C), Celldex (C), Corvus (C), Eyevensys (C), Gilead (C), Horizon (C), Janssen (C), Novartis (C), Pfizer (F), Roche (C), Santen (C), UCB (C), Up to Date (R)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 2056. doi:
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      Krati Chauhan, James Rosenbaum; Effect of age, race, sex and state of residence on ocular inflammatory and infectious diseases in the United States. Invest. Ophthalmol. Vis. Sci. 2020;61(7):2056.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : There is a lack of national level data regarding prevalence of ocular inflammatory and infectious diseases. We conducted a retrospective, observational clinical study based on the Intelligent Research in Sight (IRIS) registry. The primary aim of our study is to determine the prevalence of ocular inflammatory and infectious diseases in the United States, and whether this prevalence is influenced by age, sex, race and state of residence

Methods : IRIS is United States’ first comprehensive eye disease clinical registry. In 2016, IRIS contained more than 24.19 million patients and 88 million encounters. We have used IRIS data available through National Vision and Eye Health Surveillance system (VEHSS). VEHSS is developed by partnership of the Center for Disease Control and National Opinion Research Center (NORC) at University of Chicago.

VEHSS uses ICD-10 codes to identify ocular disorders and organizes them into two level categorization, which are category and subgroup. Each code is categorized in one subgroup and multiple subgroups are combined to form a category. Infectious and inflammatory eye disease category includes subgroups of ocular inflammatory conditions, lacrimal system and orbital inflammation, keratitis, conjunctivitis, eyelid inflammation and infection and endophthalmitis. The denominator consists of total number of current patients with an encounter with an IRIS member provider during 2016. Prevalence is stratified by age group, sex, race and state. Confidence intervals are calculated using the Clopper- Pearson exact method based on binominal distribution.

Results : There were total of 17,361,000 patients; 10,213,000 females and 7,128,000 males. Annual prevalence of inflammatory and infectious eye diseases was 14.31% (95% CI: 14.30-14.33). The 18-39 years age group had the highest prevalence at 15.76% (95% CI: 15.71 - 15.82). Asians had the highest prevalence, 17.89% (95% CI: 17.78 - 18.00). These results are summarized in table 1. Montana had the highest prevalence 22.32% (95% CI: 21.73-22.93) and Minnesota the lowest 6.35% (95% CI: 6.27-6.43). Table 2 provides top 5 states with highest and lowest prevalence.

Conclusions : Age, race, sex, and state impact eye care in the United States. This may be due to difference in disease prevalence and/or utilization of services. The differences should be considered in planning for health care delivery

This is a 2020 ARVO Annual Meeting abstract.




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