June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Retinal vasculitis (RV) in acute and non-acute Vogt-Koyanagi-Harada disease (VKHD): a cross-sectional study with multimodal analysis
Author Affiliations & Notes
  • Ruy F B G Missaka
    Ophthalmology, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil
  • Fernanda Maria Silveira Souto
    Ophthalmology, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil
  • Marcelo Mendes Lavezzo
    Ophthalmology, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil
  • Viviane Mayumi Sakata
    Ophthalmology, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil
    Ophthalmology, Faculdade de Medicina, Universidade Federal do Paraná, Curitiba, PR, Brazil
  • Priscilla Figueiredo Campos da Nóbrega
    Ophthalmology, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil
  • Maria Kiyoko Oyamada
    Ophthalmology, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil
  • Carlos Eduardo Hirata
    Ophthalmology, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil
  • Joyce H Yamamoto
    Ophthalmology, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil
  • Footnotes
    Commercial Relationships   Ruy Missaka, None; Fernanda Maria Silveira Souto, None; Marcelo Lavezzo, None; Viviane Sakata, None; Priscilla Nóbrega, None; Maria Oyamada, None; Carlos Eduardo Hirata, None; Joyce Yamamoto, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 2081. doi:
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      Ruy F B G Missaka, Fernanda Maria Silveira Souto, Marcelo Mendes Lavezzo, Viviane Mayumi Sakata, Priscilla Figueiredo Campos da Nóbrega, Maria Kiyoko Oyamada, Carlos Eduardo Hirata, Joyce H Yamamoto; Retinal vasculitis (RV) in acute and non-acute Vogt-Koyanagi-Harada disease (VKHD): a cross-sectional study with multimodal analysis. Invest. Ophthalmol. Vis. Sci. 2020;61(7):2081.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the characteristics of RV and its association with other inflammatory signs and visual function in patients with VKHD

Methods : Retrospective, cross-sectional and descriptive study with patients with VKHD followed for a minimum 2 years from disease acute onset with predefined treatment protocols. Inflammation was systematically evaluated with clinical and posterior segment imaging exams (fluorescein and indocyanine green angiographies, enhanced depth imaging optical coherence tomography). RV was defined angiographically as perivascular leakage and/or hyperfluorescence of the vessel wall. The presentation of RV was divided into acute phase (≤6 mo), non-acute phase (> 6 mo) or both phases. The location of the RV was classified as posterior pole, peripheral or both locations. To assess visual function, a full-field electroretinogram (ffERG) was performed at enrollment and at predefined intervals. Medians and range were calculated for descriptive analysis. Data were analyzed using generalized estimated equations for binary ocular data, Bonferroni correction for multiple comparison, likelihood ratio and Fisher exact tests; p-values≤ 0.05 were considered statistically significant. This study was approved by Institutional Ethics Committee and followed Helsinki declaration

Results : Fifty-four eyes (27 patients) were evaluated. Thirty eyes (55%) had RV signs; among them 16 eyes (53%) presented RV in both phases, 11 eyes (36%) only in the non-acute phase and 3 eyes only in the acute phase. Among the 16 eyes with RV in both phases, 4 eyes (25%) were localized both in the posterior pole and periphery. Relation between RV and inflammatory signs or ffERG results was not observed. On the opposite way, it was related to thinner subfoveal choroidal thickness (SFCT) (p<0.001) and lower incidence of choroidal neovascularization (CNV) (p=0.044). However, when analyzing disease different phases and RV location, RV in the non-acute phase (p=0.007) and involving periphery (p=0.031) was related with thicker SFCT at month 1. Higher incidence of CNV (p=0.024) was observed in eyes with RV in posterior pole (Table)

Conclusions : Although there are few descriptions in the literature, RV in VKHD seems not to be an unusual finding. RV in different phases and locations seems to have different implications

This is a 2020 ARVO Annual Meeting abstract.

 

 

Retinal vasculitis in patients with VKHD and its location

Retinal vasculitis in patients with VKHD and its location

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