June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Medial rectus tendon thickness measured by anterior segment optical coherence tomography as a predictor of corticosteroid response for strabismus in thyroid eye disease
Author Affiliations & Notes
  • Yoshiyuki Kitaguchi
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Takeshi Morimoto
    Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Hiroshi Shimojyo
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
  • Kohji Nishida
    Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Integrated Frontier Research for Medical Science Division, Osaka University Institute for Open and Transdisciplinary ResearchInitiatives, Suita, Osaka, Japan
  • Footnotes
    Commercial Relationships   Yoshiyuki Kitaguchi, None; Takeshi Morimoto, None; Hiroshi Shimojyo, None; Kohji Nishida, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 2121. doi:
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      Yoshiyuki Kitaguchi, Takeshi Morimoto, Hiroshi Shimojyo, Kohji Nishida; Medial rectus tendon thickness measured by anterior segment optical coherence tomography as a predictor of corticosteroid response for strabismus in thyroid eye disease. Invest. Ophthalmol. Vis. Sci. 2020;61(7):2121.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the predictability of medial rectus tendon thickness measured by anterior segment optical coherence tomography (AS-OCT) on corticosteroid response for vertical strabismus associated with thyroid eye disease (TED).

Methods : Thirteen patients with TED-induced vertical strabismus who underwent intravenous methylprednisolone therapy and/or radiotherapy, or repeated peribulbar injections of triamcinolone were retrospectively analyzed. Medial rectus tendon thickness was measured using anterior segment optical coherence tomography (CASIA2®, TOMEY, NAGOYA, JAPAN) at nasal 8.7 mm from the corneal limbus. The larger value of the left and right medial rectus muscle tendon was used for analysis. Responder group was defined as disappearance of diplopia during front view or improvement of vertical deviation angle by 5°with HESS screen test at three months following induction of corticosteroid therapy.

Results : The responder group comprised 9 patients (69%), and the non-responder group comprised 4 patients (31%). The thickness of the medial rectus tendon in the non-responder group (73±89 µm, range: 278 to 493 µm) was larger than that in the responder group (197±41 µm, range: 149-240 µm) (p=0.028, Mann-Whitney test).

Conclusions : Medial rectus muscle tendon thickness is useful parameter for prediction of corticoid response for TED-induced vertical strabismus. Studies with larger sample size is needed in the future.

This is a 2020 ARVO Annual Meeting abstract.

 

Medial rectus tendon thickenss in the non-responder and the responder group.

Medial rectus tendon thickenss in the non-responder and the responder group.

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