June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Vascular Morphology Features Associated with Aneurysms in Idiopathic Retinal Vasculitis, Aneurysms, Neuro-retinitis (IRVAN)
Author Affiliations & Notes
  • Feng Hu
    Ophthalmology, Beijing Tongren Hospital, Beijing, China
  • Ge Wang
    Ophthalmology, Beijing Tongren Hospital, Beijing, China
  • Xiaoyan Peng
    Ophthalmology, Beijing Tongren Hospital, Beijing, China
  • Footnotes
    Commercial Relationships   Feng Hu, None; Ge Wang, None; Xiaoyan Peng, None
  • Footnotes
    Support  The Capital Health Research and Development of Special (sf2018-2-1081).
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 5258. doi:
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      Feng Hu, Ge Wang, Xiaoyan Peng; Vascular Morphology Features Associated with Aneurysms in Idiopathic Retinal Vasculitis, Aneurysms, Neuro-retinitis (IRVAN). Invest. Ophthalmol. Vis. Sci. 2020;61(7):5258.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The aim of this study is to report the vascular morphology features of idiopathic retinal vasculitis, aneurysms, and neuro-retinitis (IRVAN) on fluorescein angiography.

Methods : The clinical records and fluorescein angiography analysis of identified IRVAN and control group (neuro-retinitis and retinal vasculitis, but no aneurysms) patients were retrospectively reviewed. A bifurcation abnormity on fluorescein angiography exists when the angle between the artery and its branch is <90°. The arterial diameter abnormity is defined as a distal arterial diameter larger than the proximal artery.

Results : A total of 19 eyes of 11 IRVAN patients and 18 eyes of 9 patients in the control group were analyzed. The bifurcation abnormity was present in 15 of 19 eyes of IRVAN patients and 2 of 18 eyes of the control group. The incidence was significantly different between the two groups (P<0.001). Twenty-seven of 31 bifurcation abnormities that were observed coexisted with aneurysms on the same arteries or their branches. The aneurysms tended to coexist with bifurcation abnormities in the arteries (P<0.001). The arterial diameter abnormity was present in 12 of 19 eyes in IRVAN patients, and there were none in the control group (P < 0.001). All the arterial diameter abnormities were accompanied by aneurysms.

Conclusions : Bifurcation and arterial diameter abnormities are specific presentations in IRVAN, which could be a sign supporting the diagnosis of IRVAN. Coexistence of aneurysms, bifurcation, and arterial diameter abnormities on the same arteries and their branches indicated that local mechanical forces may play an important role in their formation.

This is a 2020 ARVO Annual Meeting abstract.

 

Figure 1. Venous phase on fluorescein angiography of IRVAN patient. (A) The artery branches formed toward the proximal retinal artery on the superior and inferior temporal arteries; note the angle between arteries and the branching arteries is <90° (marked by red arrowhead). (B) The distal arterial diameter was larger than that of the proximal artery divided by the aneurysm on the inferior temporal and superior nasal
arteries (marked by a red arrow).

Figure 1. Venous phase on fluorescein angiography of IRVAN patient. (A) The artery branches formed toward the proximal retinal artery on the superior and inferior temporal arteries; note the angle between arteries and the branching arteries is <90° (marked by red arrowhead). (B) The distal arterial diameter was larger than that of the proximal artery divided by the aneurysm on the inferior temporal and superior nasal
arteries (marked by a red arrow).

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