June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Motion-free, three-dimensional optical coherence tomography imaging of retinal diseases
Author Affiliations & Notes
  • Shuichi Makita
    Computational Optics Group, Computational Optics Group, University of Tsukuba, Tsukuba, IBARAKI, Japan
  • Masahiro Miura
    Department of Ophthalmology, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan
  • Tatsuo Yamaguchi
    Topcon Corporation, Itabashi, Tokyo, Japan
  • Toshihiro Mino
    Topcon Corporation, Itabashi, Tokyo, Japan
  • Shinnosuke Azuma
    Computational Optics Group, Computational Optics Group, University of Tsukuba, Tsukuba, IBARAKI, Japan
    Topcon Corporation, Itabashi, Tokyo, Japan
  • Yoshiaki Yasuno
    Computational Optics Group, Computational Optics Group, University of Tsukuba, Tsukuba, IBARAKI, Japan
  • Footnotes
    Commercial Relationships   Shuichi Makita, Kao Corporation (F), Tomey Corporation (F), Tomey Corporation (P), Topcon Corporation (F), Yokogawa Electric Corporation (F); Masahiro Miura, Allergan (F), Novartis (R), Novartis (F), Santen Pharmaceutical Co., Ltd. (F), Senju Pharmaceutical Co.,Ltd. (F); Tatsuo Yamaguchi, Topcon Corporation (E); Toshihiro Mino, Topcon Corporation (E); Shinnosuke Azuma, Kao Corporation (F), Tomey Corporation (F), Topcon Corporation (E), Topcon Corporation (F), Yokogawa Electric Corporation (F); Yoshiaki Yasuno, Kao Corporation (F), Tomey Corporation (F), Tomey Corporation (P), Topcon Corporation (F), Yokogawa Electric Corporation (F)
  • Footnotes
    Support  JSPS grant 18K09460 and 18H01893, JST grant JPMJMI18G8
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 5265. doi:
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      Shuichi Makita, Masahiro Miura, Tatsuo Yamaguchi, Toshihiro Mino, Shinnosuke Azuma, Yoshiaki Yasuno; Motion-free, three-dimensional optical coherence tomography imaging of retinal diseases. Invest. Ophthalmol. Vis. Sci. 2020;61(7):5265.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Re-visiting the same location is essential to monitor the progress of diseases and follow up treatments. Optical coherence tomography (OCT) assess the three-dimensional micrometer-scale structure non-invasively. However, strongly suffered by the eye motion. This paper aims at demonstrating motion-free OCT imaging of retinal diseases.

Methods : The custom-made 1.0-µm swept-source OCT system with a scan speed of 100,000 A-line/s is used. The OCT probe beam was scanned along with a modified Lissajous pattern, which is designed for OCTA. The eye motion is estimated by registration of the overlapped regions. Three-dimensional volumes and en face maps of OCT images can be corrected by the estimated motion amounts. The system provides multi-functional images. In addition to OCT and OCTA, pigment and flow (PAF), which contrasts blood flow and the retinal pigment epithelium (RPE) abnormalities, and RPE-melanin images, which contrasts melanin of the RPE and in the sensory retina, are obtained. A hundred twenty-six patients with retinal abnormalities were scanned, and images were surveyed.

Results : Figure 1 shows motion-free 3D volumetric images of a myopic and branch retinal vein occlusion eyes. The motion-free volumetric OCT of myopia (Fig. 1A) visualizes the bent retinal 3D shape and atrophic region (blue arrow). RPE-melanin volumetric image (Fig.1 C) shows that there are two melano-signal spots in the sensory retina (blue arrows).
Figure 2 shows motion-free en face images of a choroidal neovascularization (CNV) subject before (Fig. 2 A, B, C) and after one month (Fig. 2. D, E, F) of intravitreal anti-VEGF injection provided by multi-contrast OCT. Motion-free images make it easy to find the location of change by the injection. Abnormal blood flow signals remain, and RPE abnormalities seem progressed (green arrows).

Conclusions : Lissajous scan OCT provides several motion-free volumetric and en face images of the posterior eye. This method will be suitable to survey the eye disease conditions.

This is a 2020 ARVO Annual Meeting abstract.

 

Fig. 1. OCT volumes of a myopic eye (A) and a subject with branch retinal occlusion (B), RPE-melanin volume (C) shows two spots in the retina.

Fig. 1. OCT volumes of a myopic eye (A) and a subject with branch retinal occlusion (B), RPE-melanin volume (C) shows two spots in the retina.

 

Fig. 2. Motion-free en face multi-functional OCT imaging results of a subject with CNV. (A, D) OCT, (B, E) PAF, (C, F) RPE-melanin images. Before (A, B, C) and after 1 month (D, E, F) of intravitreal anti-VEGF injection.

Fig. 2. Motion-free en face multi-functional OCT imaging results of a subject with CNV. (A, D) OCT, (B, E) PAF, (C, F) RPE-melanin images. Before (A, B, C) and after 1 month (D, E, F) of intravitreal anti-VEGF injection.

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