Abstract
Purpose :
To compare the response symmetry of the eyes to LBN in patients with open-angle glaucoma (OAG) and ocular hypertension (OHT).
Methods :
This is a retrospective chart review study. We screened the electronic medical records of patients who had visited a glaucoma practice at the New York Eye and Ear Infirmary of Mount Sinai between 1/1/2018 to 12/31/2018. We included 42 eyes of 21 patients with OAG (19) and OHT (2). We selected adult patients who had received LBN once daily bilaterally for a minimum of ten consecutive days. Exclusion criteria were the use of steroids of any type within the timeline of LBN use, the use of additional anti-glaucoma medication after initiation of LBN, increasing the dosage of steroids in patients currently using steroids, any IOP lowering procedures including laser therapy, and having a different diagnosis in the eyes. We calculated the difference of IOP change between the right and the left eye of each patient and compared these measures with zero (no IOP difference between the two eyes) by using the single-sample t-test. We used the paired t-test to compare the baseline and the follow-up IOP levels and the duration of the treatment in each eye. We considered p-value <0.05 as significant.
Results :
The baseline and follow up IOP, and the duration of the treatment was comparable in the right and the left eyes (Table 1). The mean ± SD of the difference in the percentage of IOP change between the right and the left eyes was 16.88 ± 11.22 and was statistically significant (p < .00001; Figure 1). Of the 21 patients, only one patient showed the same degree of change in IOP after using LBN in both eyes.
Conclusions :
Our study showed that the right and the left eye does not respond similarly to LBN 0.024%.
This is a 2020 ARVO Annual Meeting abstract.