June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Evaluation of a combined anterior segment OCT and aberrometer using the same light source
Author Affiliations & Notes
  • Giulia Belloni
    Department of Engineering "Enzo Ferrari", Università degli studi di Modena e Reggio Emilia, Modena, Italy
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Brandon Chou
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Larissa Meza
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Yu-Cherng Chang
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Heather Ann Durkee
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Jean-Marie A Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Brien Holden Vision Institute Limited, Sidney, New South Wales, Australia
  • Fabrice Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Marco Ruggeri
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Footnotes
    Commercial Relationships   Giulia Belloni, None; Brandon Chou, None; Larissa Meza, None; Yu-Cherng Chang, None; Heather Durkee, None; Jean-Marie Parel, None; Fabrice Manns, None; Marco Ruggeri, None
  • Footnotes
    Support  National Eye Institute R21EY027957, 1F30EY027162 and P30EY14801 (Center Core Grant); the Florida Lions Eye Bank and Beauty of Sight Foundation; the Henri and Flore Lesieur Foundation (JMP); Drs. Raksha Urs and Aaron Furtado; Karl R. Olsen, MD and Martha E. Hildebrandt, PhD; an unrestricted grant from Research to Prevent Blindness; Australian Federal Government Cooperative Research Centre Scheme through the Vision Cooperative Research Centre.
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 1705. doi:
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      Giulia Belloni, Brandon Chou, Larissa Meza, Yu-Cherng Chang, Heather Ann Durkee, Jean-Marie A Parel, Fabrice Manns, Marco Ruggeri; Evaluation of a combined anterior segment OCT and aberrometer using the same light source. Invest. Ophthalmol. Vis. Sci. 2020;61(7):1705.

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Abstract

Purpose : The design of the current intraoperative OCTs and aberrometers prevent their combined use. The purpose of this study is to demonstrate the proof-of-concept of a combined anterior segment OCT and aberrometer that addresses this barrier by using a single light source.

Methods : We built a combined SD-OCT system and Hartmann-Shack (HS) aberrometer that uses a single light beam. The system operates at a wavelength of 840nm. The beam is focused in the pupil plane to produce high-contrast OCT images of the anterior segment. The HS sensor collects part of the light returning from the retina to measure aberrations. The difference with standard HS aberrometers is that the beam reaching the retina is defocused. We tested the aberrometer on a model eye that provides controlled amount of defocus and cylinder in the range between -16D and +32D and -5D to +5D, respectively. To assess the accuracy of the system, we compared the power vectors (M, J0 and J45) measured on 11 human subjects (total eyes = 22, age range: 29.73 ± 10.11 y/o, SE range: -9D to 0D) to those obtained using a clinical autorefractor (KR-800, Topcon). To evaluate intrasession repeatability, we acquired 5 consecutive refraction measurements on the right eye of a 43 y/o subject (SE = -3D). The same operator acquired 5 measurements on the same subject at 30-minute intervals to assess intersession repeatability. Each session consisted of 5 consecutive measurements.

Results : The aberrometer provides a linear measurement response (y = 1.006x + 0.0054) with residuals of less than ±0.35D in the sphere range of the eye model. The maximum absolute differences between theoretical and measured values of cylinder at the end of the cylinder range are 1.25, 0.40 and 1.85 D, for -16, 0 and +32D values of spheres, respectively. Correlation plots from Bland-Altman analysis (Fig. A) show mean differences between the measurements obtained with the two systems of 1.03, 0.08 and 0.03D for M, J0 and J45, respectively. The 95% confidence limits of agreement were ± 1.29, ± 1.02 and ± 0.63 D (M, J0 and J45). Intra- and Inter-session repeatability analysis yielded standard deviations of 0.02, 0.21, 0.24 D (M, J0, J45) and 0.11, 0.25, 0.21 D (M, J0 and J45), respectively. Fig. B shows a full-depth OCT image of the anterior segment of a 50 y/o subject.

Conclusions : We demonstrated the proof-of-principle of combined anterior segment OCT and autorefraction using a single beam.

This is a 2020 ARVO Annual Meeting abstract.

 

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