June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Central versus peripheral macular structure and function: acuity in age-related macular degeneration
Author Affiliations & Notes
  • Ted Maddess
    John Curtin School, Neuroscience, Australian National University, Lyneham, Australian Capital Territory, Australia
  • Jo Lane
    Research School of Psychology, Australian National University, Canberra, Australian Capital Territory, Australia
    ARC Centre of Excellence in Cognition and its Disorders, Australian National University, Canberra, Australian Capital Territory, Australia
  • Emilie Marie Frances Rohan
    John Curtin School, Neuroscience, Australian National University, Lyneham, Australian Capital Territory, Australia
    Orthoptics, La Trobe University, Melbourne, Victoria, Australia
  • Rohan W Essex
    Academic Unit of Ophthalmology, The Canberra Hospital, Canberra, Australian Capital Territory, Australia
  • Elinor McKone
    Research School of Psychology, Australian National University, Canberra, Australian Capital Territory, Australia
    ARC Centre of Excellence in Cognition and its Disorders, Australian National University, Canberra, Australian Capital Territory, Australia
  • Faran Sabeti
    Discipline of Optometry, Faculty of Health, University of Canberra, Canberra, Australian Capital Territory, Australia
    John Curtin School, Neuroscience, Australian National University, Lyneham, Australian Capital Territory, Australia
  • Footnotes
    Commercial Relationships   Ted Maddess, EyeCo Pty Ltd (I), Konan Medical USA Inc (F), Konan Medical USA Inc (P); Jo Lane, None; Emilie Rohan, None; Rohan Essex, None; Elinor McKone, None; Faran Sabeti, Konan Medical USA Inc (F)
  • Footnotes
    Support  ARC Centre of Excellence in Cognition and its disorders (CE110001021, DP150100684), NHMRC Project grant (1028560), and Rebecca Cooper Medical Foundation Grant (PG2018040)
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3007. doi:
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    • Get Citation

      Ted Maddess, Jo Lane, Emilie Marie Frances Rohan, Rohan W Essex, Elinor McKone, Faran Sabeti; Central versus peripheral macular structure and function: acuity in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3007.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Patients with neovascular age-related macular degeneration (nAMD) may have preserved visual function despite significant retinal structural changes. We aimed to evaluate the relationships between retinal thickness, macular sensitivity, and visual acuity in nAMD.

Methods : We examined 44 nAMD-affected eyes from 22 patients (ages 66–93 years) selected to cover the full range of vision loss. Visual function was measured on participants with low and high contrast visual acuity (HCVA) and 10-2 Matrix visual fields. Retinal structure was determined with Spectralis spectral domain optical coherence tomography (OCT), and customized software mapped the 64 OCT macular thickness regions onto the 44 regions of the 10-2 test, permitting structure function correlations to be directly calculated.

Results : Median thickness at each 10-2 region was near normal. Just 7/88 regions from the OCT analysis that were thicker than the median had sensitivity that declined significantly with increasing thickness (r=-0.698 ± 0.082, mean ± SD, e.g. Figure), while 17/88 thinner regions showed significantly decreasing sensitivity with decreasing thickness (r=0.723 ± 0.078). The absolute value of deviations from median optical coherence tomography thickness (aOCT) was significantly negatively correlated with HCVA outside the central 8 degrees (r=-0.31, P=0.044), but not within the central 8 degrees. Similarly Matrix sensitivities outside the central 8 degrees were significantly negatively correlated with aOCT (r=-0.32, P=0.032) but not inner regions.

Conclusions : Our results show that retinal thickness outside 8 degrees was significantly associated with HCVA and macular sensitivity. These results suggest that outer macular thickness and sensitivity (> 8 degrees) may be useful prognostic indicator.

This is a 2020 ARVO Annual Meeting abstract.

 

A) The medians for left eyes across thicker than average retinal regions of the 64 OCT (3x3 degree) macular thickness measures mapped onto the 44 Matrix (2x2 degree) visual field regions for direct comparison with the (B) median Matrix sensitivity measurements. C) Correlations between the sensitivity and thickness data. ‘*’ indicates significant correlations (p<0.05).

A) The medians for left eyes across thicker than average retinal regions of the 64 OCT (3x3 degree) macular thickness measures mapped onto the 44 Matrix (2x2 degree) visual field regions for direct comparison with the (B) median Matrix sensitivity measurements. C) Correlations between the sensitivity and thickness data. ‘*’ indicates significant correlations (p<0.05).

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