Purchase this article with an account.
Ted Maddess, Jo Lane, Emilie Marie Frances Rohan, Rohan W Essex, Elinor McKone, Faran Sabeti; Central versus peripheral macular structure and function: acuity in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3007.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Patients with neovascular age-related macular degeneration (nAMD) may have preserved visual function despite significant retinal structural changes. We aimed to evaluate the relationships between retinal thickness, macular sensitivity, and visual acuity in nAMD.
We examined 44 nAMD-affected eyes from 22 patients (ages 66–93 years) selected to cover the full range of vision loss. Visual function was measured on participants with low and high contrast visual acuity (HCVA) and 10-2 Matrix visual fields. Retinal structure was determined with Spectralis spectral domain optical coherence tomography (OCT), and customized software mapped the 64 OCT macular thickness regions onto the 44 regions of the 10-2 test, permitting structure function correlations to be directly calculated.
Median thickness at each 10-2 region was near normal. Just 7/88 regions from the OCT analysis that were thicker than the median had sensitivity that declined significantly with increasing thickness (r=-0.698 ± 0.082, mean ± SD, e.g. Figure), while 17/88 thinner regions showed significantly decreasing sensitivity with decreasing thickness (r=0.723 ± 0.078). The absolute value of deviations from median optical coherence tomography thickness (aOCT) was significantly negatively correlated with HCVA outside the central 8 degrees (r=-0.31, P=0.044), but not within the central 8 degrees. Similarly Matrix sensitivities outside the central 8 degrees were significantly negatively correlated with aOCT (r=-0.32, P=0.032) but not inner regions.
Our results show that retinal thickness outside 8 degrees was significantly associated with HCVA and macular sensitivity. These results suggest that outer macular thickness and sensitivity (> 8 degrees) may be useful prognostic indicator.
This is a 2020 ARVO Annual Meeting abstract.
A) The medians for left eyes across thicker than average retinal regions of the 64 OCT (3x3 degree) macular thickness measures mapped onto the 44 Matrix (2x2 degree) visual field regions for direct comparison with the (B) median Matrix sensitivity measurements. C) Correlations between the sensitivity and thickness data. ‘*’ indicates significant correlations (p<0.05).
This PDF is available to Subscribers Only