June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Effect of a spatial filter on test-retest variability in glaucomatous patients
Author Affiliations & Notes
  • CHIARA RUI
    Centervue SpA, Italy
  • Francesco Oddone
    Glaucoma Unit, IRCCS GB Bietti Eye Foundation, Rome, Italy
  • Antonio Modarelli
    Eye Clinic, Univeristy of Milan, Milan, Italy
  • Roberta Farci
    Eye Clinic, Univeristy of Milan, Milan, Italy
  • Paolo Fogagnolo
    Eye Clinic, Univeristy of Milan, Milan, Italy
  • Luca Mario Rossetti
    Eye Clinic, Univeristy of Milan, Milan, Italy
  • Footnotes
    Commercial Relationships   CHIARA RUI, Centervue SpA (E); Francesco Oddone, Centervue SpA (C); Antonio Modarelli, None; Roberta Farci, None; Paolo Fogagnolo, Centervue SpA (C); Luca Mario Rossetti, Centervue SpA (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3880. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      CHIARA RUI, Francesco Oddone, Antonio Modarelli, Roberta Farci, Paolo Fogagnolo, Luca Mario Rossetti; Effect of a spatial filter on test-retest variability in glaucomatous patients. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3880.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To compare the variability of multiple visual fields (VFs) results obtained using Compass fundus perimeter (CMP, Centervue, Italy) with and without the application of a dedicated post-processing filter based on the spatial interpoint correlations of thresholds values

Methods : 45 patients with glaucoma (Mean Sensitivity Range [5.81; 28.63] dB; Mean Deviation Range [-22.03; 0.98] dB) underwent six VFs with CMP over a period of about two months on one eye (randomly chosen). 24-2 VFs with additional macular points (24-2+ grid) were collected using Zippy Estimation by Sequential Testing (ZEST) algorithm. Unreliable visual field tests (FP > 18%, FN > 30%) were excluded and VFs assessed at the first visit were not included to avoid learning effect. A total of 225 VFs (5 VFs for each patient) were analyzed before and after the post-processing elaboration for both the 24-2+ Grid and the standard 24-2 grid (subset of 24-2+). Test-retest variability of 180 couples of VFs was evaluated both globally with Mean Sensitivity (MS) and pointwise (thresholds) with Bland-Altman technique. The results were compared in order to evaluate the impact of the filter procedure on test-retest variability

Results : Variability of unfiltered CMP data changed as a function of the thresholds values. Pointwise test-retest limits of agreement for the 24-2+ and the 24-2 grids were reduced by 22.5% and 25.9% respectively (Figure 1). Global test-retest variability of MS was increased by 3.25% and 3.53% respectively (Figure 2). The Bland-Altman dynamic range of pointwise thresholds pre and post filter was the same: [-1; 37] dB for 24-2+ grid and [-1; 35] dB for 24-2 grid. For the MS the dynamic range pre and post filter was [6.5; 28.3] dB and [6.2; 28.2] dB respectively for 24-2+ grid and [4.9; 27.4] dB and [4.5; 27.2] dB respectively for 24-2 grid

Conclusions : The filter procedure improves pointwise test-retest variability, preserving the dynamic range. As expected, the effect on MS was minimal. Further validation on longitudinal series is needed to assess its effect on progression detection

This is a 2020 ARVO Annual Meeting abstract.

 

Bland-Altman of Compass pointwise thresholds: 24-2+ grid, Pre-filter (top left) and Post-filter (top right) and 24-2 grid, Pre-filter (bottom left) and Post-filter (bottom right)

Bland-Altman of Compass pointwise thresholds: 24-2+ grid, Pre-filter (top left) and Post-filter (top right) and 24-2 grid, Pre-filter (bottom left) and Post-filter (bottom right)

 

Bland-Altman of Compass MS: 24-2+ grid, Pre-filter (top left) and Post-filter (top right) and 24-2 grid, Pre-filter (bottom left) and Post-filter (bottom right)

Bland-Altman of Compass MS: 24-2+ grid, Pre-filter (top left) and Post-filter (top right) and 24-2 grid, Pre-filter (bottom left) and Post-filter (bottom right)

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×