June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Repeatability of Peripapillary Vessel Parameters by Optical Coherence Tomography Angiography
Author Affiliations & Notes
  • Jae Chang Lee
    USC Roski Eye Institute, Keck Medicine of University of Southern California, Los Angeles, California, United States
  • Dominic Joseph Grisafe
    USC Roski Eye Institute, Keck Medicine of University of Southern California, Los Angeles, California, United States
  • Bruce Burkemper
    USC Roski Eye Institute, Keck Medicine of University of Southern California, Los Angeles, California, United States
  • Brenda Ryuna Chang
    USC Roski Eye Institute, Keck Medicine of University of Southern California, Los Angeles, California, United States
  • Ali Fard
    Carl Zeiss Meditec, Inc., Dublin, California, United States
  • Zhongdi Chu
    Department of Bioengineering, University of Washington, Seattle, Washington, United States
  • Xiao Zhou
    Department of Bioengineering, University of Washington, Seattle, Washington, United States
  • Ruikang K Wang
    Department of Bioengineering, University of Washington, Seattle, Washington, United States
  • Grace Marie Richter
    USC Roski Eye Institute, Keck Medicine of University of Southern California, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Jae Lee, None; Dominic Grisafe, None; Bruce Burkemper, None; Brenda Chang, None; Ali Fard, Carl Zeiss Meditec (E); Zhongdi Chu, None; Xiao Zhou, None; Ruikang Wang, Carl Zeiss Meditec (C), Carl Zeiss Meditec (P), Carl Zeiss Meditec (F); Grace Richter, Carl Zeiss Meditec (F)
  • Footnotes
    Support  NIH Grant 5K23EY027855-03; Multidisciplinary Research Training in Gerontology, National Institute on Aging (NIA T32 AG000037 – Crimmins, PI – 50% FTE);
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3907. doi:
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      Jae Chang Lee, Dominic Joseph Grisafe, Bruce Burkemper, Brenda Ryuna Chang, Ali Fard, Zhongdi Chu, Xiao Zhou, Ruikang K Wang, Grace Marie Richter; Repeatability of Peripapillary Vessel Parameters by Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3907.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare intrasession repeatability of the peripapillary vessel parameters of optical coherence tomography angiography (OCTA) in glaucoma and non-glaucoma subjects.

Methods : An observational, cross-sectional study collected three 6x6mm optic nerve head (ONH) OCTA scans (Cirrus HD-OCT 5000) of glaucoma and non-glaucoma subjects. En face images of the radial peripapillary capillary (RPC) layer were created using a commercially provided automatic segmentation software. A custom image quality grading protocol excluded eyes with media opacities, segmentation errors, or motion artifacts. Subjects with non-glaucomatous optic neuropathy, diabetic retinopathy, and other retinal pathologies were excluded. The commercially provided quantification software calculated perfusion density (PD) and flux index (FI); custom quantification software calculated vessel area density (VAD) and flux. Repeatability was measured by intraclass correlation coefficient (ICC), within-subject standard deviation (Sw), coefficient of repeatability (CRw), and coefficient of variation (CVw).

Results : One eye was chosen at random from each subject. Of 193 subjects, 159 subjects had at least two good quality intrasession images. Of these, 88 met the inclusion and exclusion criteria (29 non-glaucoma, 59 glaucoma). The Sw [%], and ICC of the commercially available segmentation algorithms in non-glaucoma eyes for PD were 0.006, and 0.939, respectively, and for FI were 0.006, and 0.954. The Sw [%], and ICC in glaucoma eyes for PD were 0.007, and 0.965, and for FI were 0.007, and 0.969. The Sw [%], and ICC of the custom segmentation software in non-glaucoma eyes for VAD were 0.019, and 0.858, respectively, and for flux were 0.008, and 0.864. The Sw [%], and ICC in glaucoma eyes for VAD were 0.012, and 0.972, and for flux were 0.004, and 0.976.

Conclusions : OCTA parameters were highly repeatable during the same visit. Furthermore, repeatability measurements were similar for both commercially provided and custom quantification software. ICCs tended to be higher among glaucoma subjects compared to non-glaucoma subjects, which may be explained by the larger between-subject variability in the glaucoma group.

This is a 2020 ARVO Annual Meeting abstract.

 

Table 1 Repeatability estimates of peripapillary vessel parameters

Table 1 Repeatability estimates of peripapillary vessel parameters

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